| RRC ID |
76203
|
| Author |
Ju S, Chen H, Wang S, Lin J, Ma Y, Aroian RV, Peng D, Sun M.
|
| Title |
C. elegans monitor energy status via the AMPK pathway to trigger innate immune responses against bacterial pathogens.
|
| Journal |
Commun Biol
|
| Abstract |
Pathogen recognition and the triggering of host innate immune system are critical to understanding pathogen-host interaction. Cellular surveillance systems have been identified as an important strategy for the identification of microbial infection. In the present study, using Bacillus thuringiensis-Caenorhabditis elegans as a model, we found an approach for surveillance systems to sense pathogens. We report that Bacillus thuringiensis Cry5Ba, a typical pore-forming toxin, caused mitochondrial damage and energy imbalance by triggering potassium ion leakage, instead of directly targeting mitochondria. Interestingly, we find C. elegans can monitor intracellular energy status to trigger innate immune responses via AMP-activated protein kinase (AMPK), secreting multiple effectors to defend against pathogenic attacks. Our study indicates that the imbalance of energy status is a prevalent side effect of pathogen infection. Furthermore, the AMPK-dependent surveillance system may serve as a practicable strategy for the host to recognize and defense against pathogens.
|
| Volume |
5(1)
|
| Pages |
643
|
| Published |
2022-6-30
|
| DOI |
10.1038/s42003-022-03589-1
|
| PII |
10.1038/s42003-022-03589-1
|
| PMID |
35773333
|
| PMC |
PMC9246835
|
| MeSH |
AMP-Activated Protein Kinases / metabolism
Animals
Bacillus thuringiensis* / metabolism
Caenorhabditis elegans / metabolism
Caenorhabditis elegans Proteins* / genetics
Caenorhabditis elegans Proteins* / metabolism
Immunity, Innate
|
| Resource |
| C.elegans |
tm1944
tm2658
tm5269 |
