論文 - 詳細
| RRC ID | 76212 |
|---|---|
| 著者 | Lalsiamthara J, Aballay A. |
| タイトル | The gut efflux pump MRP-1 exports oxidized glutathione as a danger signal that stimulates behavioral immunity and aversive learning. |
| ジャーナル | Commun Biol |
| Abstract |
Innate immune surveillance, which monitors the presence of potentially harmful microorganisms and the perturbations of host physiology that occur in response to infections, is critical to distinguish pathogens from beneficial microbes. Here, we show that multidrug resistance-associated protein-1 (MRP-1) functions in the basolateral membrane of intestinal cells to transport byproducts of cellular redox reactions to control both molecular and behavioral immunity in Caenorhabditis elegans. Pseudomonas aeruginosa infection disrupts glutathione homeostasis, leading to the excess production of the MRP-1 substrate, oxidized glutathione (GSSG). Extracellular GSSG triggers pathogen avoidance behavior and primes naïve C. elegans to induce aversive learning behavior via neural NMDA class glutamate receptor-1 (NMR-1). Our results indicate that MRP-1 transports GSSG, which acts as a danger signal capable of warning C. elegans of changes in intestinal homeostasis, thereby initiating a gut neural signal that elicits an appropriate host defense response. |
| 巻・号 | 5(1) |
| ページ | 422 |
| 公開日 | 2022-5-5 |
| DOI | 10.1038/s42003-022-03381-1 |
| PII | 10.1038/s42003-022-03381-1 |
| PMID | 35513700 |
| PMC | PMC9072357 |
| MeSH | Animals Avoidance Learning Caenorhabditis elegans* / metabolism Caenorhabditis elegans Proteins* / metabolism Glutathione Disulfide Multidrug Resistance-Associated Proteins / metabolism Oxidation-Reduction |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 8 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm12751 tm5488 tm7541 |