| RRC ID |
76238
|
| Author |
Matty MA, Lau HE, Haley JA, Singh A, Chakraborty A, Kono K, Reddy KC, Hansen M, Chalasani SH.
|
| Title |
Intestine-to-neuronal signaling alters risk-taking behaviors in food-deprived Caenorhabditis elegans.
|
| Journal |
PLoS Genet
|
| Abstract |
Animals integrate changes in external and internal environments to generate behavior. While neural circuits detecting external cues have been mapped, less is known about how internal states like hunger are integrated into behavioral outputs. Here, we use the nematode C. elegans to examine how changes in internal nutritional status affect chemosensory behaviors. We show that acute food deprivation leads to a reversible decline in repellent, but not attractant, sensitivity. This behavioral change requires two conserved transcription factors MML-1 (MondoA) and HLH-30 (TFEB), both of which translocate from the intestinal nuclei to the cytoplasm during food deprivation. Next, we identify the insulin-like peptide INS-31 as a candidate ligand relaying food-status signals from the intestine to other tissues. Further, we show that neurons likely use the DAF-2 insulin receptor and AGE-1/PI-3 Kinase, but not DAF-16/FOXO to integrate these intestine-released peptides. Altogether, our study shows how internal food status signals are integrated by transcription factors and intestine-neuron signaling to generate flexible behaviors via the gut-brain axis.
|
| Volume |
18(5)
|
| Pages |
e1010178
|
| Published |
2022-5-1
|
| DOI |
10.1371/journal.pgen.1010178
|
| PII |
PGENETICS-D-21-01159
|
| PMID |
35511794
|
| PMC |
PMC9070953
|
| MeSH |
Animals
Basic Helix-Loop-Helix Transcription Factors
Caenorhabditis elegans* / genetics
Caenorhabditis elegans Proteins* / genetics
Forkhead Transcription Factors
Insulin
Intestines
Risk-Taking
Transcription Factors / genetics
|
| Resource |
| C.elegans |
tm1516
tm1978
tm3603
tm339
tm3620
tm2416
tm3498
tm790
tm1875
tm3543
tm2001
tm4144
tm6061
tm1053 |
