| RRC ID |
76244
|
| Author |
Miller HA, Huang S, Dean ES, Schaller ML, Tuckowski AM, Munneke AS, Beydoun S, Pletcher SD, Leiser SF.
|
| Title |
Serotonin and dopamine modulate aging in response to food odor and availability.
|
| Journal |
Nat Commun
|
| Abstract |
An organism's ability to perceive and respond to changes in its environment is crucial for its health and survival. Here we reveal how the most well-studied longevity intervention, dietary restriction, acts in-part through a cell non-autonomous signaling pathway that is inhibited by the presence of attractive smells. Using an intestinal reporter for a key gene induced by dietary restriction but suppressed by attractive smells, we identify three compounds that block food odor effects in C. elegans, thereby increasing longevity as dietary restriction mimetics. These compounds clearly implicate serotonin and dopamine in limiting lifespan in response to food odor. We further identify a chemosensory neuron that likely perceives food odor, an enteric neuron that signals through the serotonin receptor 5-HT1A/SER-4, and a dopaminergic neuron that signals through the dopamine receptor DRD2/DOP-3. Aspects of this pathway are conserved in D. melanogaster. Thus, blocking food odor signaling through antagonism of serotonin or dopamine receptors is a plausible approach to mimic the benefits of dietary restriction.
|
| Volume |
13(1)
|
| Pages |
3271
|
| Published |
2022-6-7
|
| DOI |
10.1038/s41467-022-30869-5
|
| PII |
10.1038/s41467-022-30869-5
|
| PMID |
35672307
|
| PMC |
PMC9174215
|
| MeSH |
Aging
Animals
Caenorhabditis elegans* / genetics
Caenorhabditis elegans Proteins* / genetics
Caenorhabditis elegans Proteins* / metabolism
Dopamine / metabolism
Drosophila melanogaster / metabolism
Longevity / genetics
Odorants
Receptors, Dopamine / metabolism
Serotonin / metabolism
|
| Resource |
| C.elegans |
tm1392 |
