論文 - 詳細
| RRC ID | 76274 |
|---|---|
| 著者 | Rahman M, Ramirez-Suarez NJ, Diaz-Balzac CA, Bülow HE. |
| タイトル | Specific N-glycans regulate an extracellular adhesion complex during somatosensory dendrite patterning. |
| ジャーナル | EMBO Rep |
| Abstract |
N-glycans are molecularly diverse sugars borne by over 70% of proteins transiting the secretory pathway and have been implicated in protein folding, stability, and localization. Mutations in genes important for N-glycosylation result in congenital disorders of glycosylation that are often associated with intellectual disability. Here, we show that structurally distinct N-glycans regulate an extracellular protein complex involved in the patterning of somatosensory dendrites in Caenorhabditis elegans. Specifically, aman-2/Golgi alpha-mannosidase II, a conserved key enzyme in the biosynthesis of specific N-glycans, regulates the activity of the Menorin adhesion complex without obviously affecting the protein stability and localization of its components. AMAN-2 functions cell-autonomously to allow for decoration of the neuronal transmembrane receptor DMA-1/LRR-TM with the correct set of high-mannose/hybrid/paucimannose N-glycans. Moreover, distinct types of N-glycans on specific N-glycosylation sites regulate DMA-1/LRR-TM receptor function, which, together with three other extracellular proteins, forms the Menorin adhesion complex. In summary, specific N-glycan structures regulate dendrite patterning by coordinating the activity of an extracellular adhesion complex, suggesting that the molecular diversity of N-glycans can contribute to developmental specificity in the nervous system. |
| 巻・号 | 23(7) |
| ページ | e54163 |
| 公開日 | 2022-7-5 |
| DOI | 10.15252/embr.202154163 |
| PMID | 35586945 |
| PMC | PMC9253746 |
| MeSH | Amantadine / metabolism Animals Caenorhabditis elegans* / metabolism Caenorhabditis elegans Proteins* / metabolism Dendrites / metabolism Membrane Proteins / genetics Membrane Proteins / metabolism Polysaccharides / chemistry Polysaccharides / metabolism |
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1078 tm5159 |