| RRC ID |
76297
|
| 著者 |
Song M, Dong S, Zhang X, Dai Y, Zhang X, Shen Y.
|
| タイトル |
A moderate static magnetic field promotes C. elegans longevity through cytochrome P450s.
|
| ジャーナル |
Sci Rep
|
| Abstract |
Ageing is co-regulated by genetic and environmental factors. Life on earth lives and evolves in a mild geomagnetic field. Yet, the biological effects of a moderate magnetic field on ageing and the underlying genetic mechanisms remain barely unknown. Here, we report that a moderate static magnetic field (SMF) extends the lifespan of Caenorhabditis elegans, a well-established model organism in ageing research. Consistently, the SMF-treated worms show improved motility and mitochondrial function when aged. We identified from the transcriptomic changes upon SMF treatment that the upregulation of three cytochrome P450 genes are required for SMF-induced longevity. Our findings thus reveal that proper SMF treatment could promote longevity through the well-conserved cytochrome P450 enzymes.
|
| 巻・号 |
12(1)
|
| ページ |
16108
|
| 公開日 |
2022-9-27
|
| DOI |
10.1038/s41598-022-20647-0
|
| PII |
10.1038/s41598-022-20647-0
|
| PMID |
36167800
|
| PMC |
PMC9515093
|
| MeSH |
Animals
Caenorhabditis elegans* / physiology
Caenorhabditis elegans Proteins* / genetics
Cytochrome P-450 Enzyme System / genetics
Longevity / genetics
Magnetic Fields
|
| リソース情報 |
| 線虫 |
tm6890
tm6902 |
