論文 - 詳細
| RRC ID | 76314 |
|---|---|
| 著者 | Uma Naresh N, Kim S, Shpilka T, Yang Q, Du Y, Haynes CM. |
| タイトル | Mitochondrial genome recovery by ATFS-1 is essential for development after starvation. |
| ジャーナル | Cell Rep |
| Abstract |
Nutrient availability regulates the C. elegans life cycle as well as mitochondrial physiology. Food deprivation significantly reduces mitochondrial genome (mtDNA) numbers and leads to aging-related phenotypes. Here we show that the bZIP (basic leucine zipper) protein ATFS-1, a mediator of the mitochondrial unfolded protein response (UPRmt), is required to promote growth and establish a functional germline after prolonged starvation. We find that recovery of mtDNA copy numbers and development after starvation requires mitochondrion-localized ATFS-1 but not its nuclear transcription activity. We also find that the insulin-like receptor DAF-2 functions upstream of ATFS-1 to modulate mtDNA content. We show that reducing DAF-2 activity represses ATFS-1 nuclear function while causing an increase in mtDNA content, partly mediated by mitochondrion-localized ATFS-1. Our data indicate the importance of the UPRmt in recovering mitochondrial mass and suggest that atfs-1-dependent mtDNA replication precedes mitochondrial network expansion after starvation. |
| 巻・号 | 41(13) |
| ページ | 111875 |
| 公開日 | 2022-12-27 |
| DOI | 10.1016/j.celrep.2022.111875 |
| PII | S2211-1247(22)01771-5 |
| PMID | 36577367 |
| PMC | PMC9922093 |
| MeSH | Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins* / genetics Caenorhabditis elegans Proteins* / metabolism DNA, Mitochondrial / genetics DNA, Mitochondrial / metabolism Genome, Mitochondrial* Mitochondria / genetics Mitochondria / metabolism Unfolded Protein Response |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 10 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.2 |
| リソース情報 | |
| 線虫 | tm598 |