| RRC ID |
76315
|
| Author |
Une R, Kageyama N, Ono M, Matsunaga Y, Iwasaki T, Kawano T.
|
| Title |
The FMRFamide-like peptide FLP-1 modulates larval development by regulating the production and secretion of the insulin-like peptide DAF-28 in Caenorhabditis elegans.
|
| Journal |
Biosci Biotechnol Biochem
|
| Abstract |
The FMRFamide-like peptides (FLPs) are conserved in both free-living and parasitic nematodes. This molecular genetic study verified the relevance of the flp-1 gene, which is conserved in many nematode species, to the larval development of the free-living soil nematode Caenorhabditis elegans. Using C. elegans as a model, we found that: (1) FLP-1 suppressed larval development, resulting in diapause; (2) the secretion of FLP-1, which is produced in AVK head neurons, was suppressed by the presence of food (Escherichia coli) as an environmental factor to continue larval development; (3) the FLP-1 reduced the production and secretion of DAF-28, which is produced in ASI head neurons and is the predominant insulin-like peptide (INS) present. FLP-1 is conserved in many species of plant-parasitic root-knot nematodes that cause severe damage to crops. Therefore, our findings may provide insight into the development of new nematicides that can disturb their infection and development.
|
| Volume |
87(2)
|
| Pages |
171-178
|
| Published |
2023-1-24
|
| DOI |
10.1093/bbb/zbac187
|
| PII |
6888007
|
| PMID |
36507740
|
| MeSH |
Animals
Caenorhabditis elegans / genetics
Caenorhabditis elegans Proteins* / genetics
FMRFamide / chemistry
FMRFamide / genetics
Insulin
Nematoda* / genetics
Neuropeptides*
Peptides
|
| Resource |
| C.elegans |
|
