| RRC ID |
76321
|
| 著者 |
Wang SY, Kim K, O'Brown ZK, Levan A, Dodson AE, Kennedy SG, Chernoff C, Greer EL.
|
| タイトル |
Hypoxia induces transgenerational epigenetic inheritance of small RNAs.
|
| ジャーナル |
Cell Rep
|
| Abstract |
Animals sense and adapt to decreased oxygen availability, but whether and how hypoxia exposure in ancestors can elicit phenotypic consequences in normoxia-reared descendants are unclear. We show that hypoxia educes an intergenerational reduction in lipids and a transgenerational reduction in fertility in the nematode Caenorhabditis elegans. The transmission of these epigenetic phenotypes is dependent on repressive histone-modifying enzymes and the argonaute HRDE-1. Feeding naive C. elegans small RNAs extracted from hypoxia-treated worms is sufficient to induce a fertility defect. Furthermore, the endogenous small interfering RNA F44E5.4/5 is upregulated intergenerationally in response to hypoxia, and soaking naive normoxia-reared C. elegans with F44E5.4/5 double-stranded RNA (dsRNA) is sufficient to induce an intergenerational fertility defect. Finally, we demonstrate that labeled F44E5.4/5 dsRNA is itself transmitted from parents to children. Our results suggest that small RNAs respond to the environment and are sufficient to transmit non-genetic information from parents to their naive children.
|
| 巻・号 |
41(11)
|
| ページ |
111800
|
| 公開日 |
2022-12-13
|
| DOI |
10.1016/j.celrep.2022.111800
|
| PII |
S2211-1247(22)01688-6
|
| PMID |
36516753
|
| PMC |
PMC9847139
|
| MeSH |
Animals
Caenorhabditis elegans* / genetics
Caenorhabditis elegans* / metabolism
Caenorhabditis elegans Proteins* / genetics
Caenorhabditis elegans Proteins* / metabolism
Epigenesis, Genetic
Hypoxia / genetics
Inheritance Patterns
RNA Interference
RNA, Double-Stranded / genetics
RNA, Small Interfering / genetics
|
| リソース情報 |
| 線虫 |
tm1200
tm3121
tm4259
tm2238
tm894 |
