論文 - 詳細
| RRC ID | 76337 |
|---|---|
| 著者 | Zapata RC, Carretero M, Reis FCG, Chaudry BS, Ofrecio J, Zhang D, Sasik R, Ciaraldi T, Petrascheck M, Osborn O. |
| タイトル | Adipocytes control food intake and weight regain via Vacuolar-type H+ ATPase. |
| ジャーナル | Nat Commun |
| Abstract |
Energy metabolism becomes dysregulated in individuals with obesity and many of these changes persist after weight loss and likely play a role in weight regain. In these studies, we use a mouse model of diet-induced obesity and weight loss to study the transcriptional memory of obesity. We found that the 'metabolic memory' of obesity is predominantly localized in adipocytes. Utilizing a C. elegans-based food intake assay, we identify 'metabolic memory' genes that play a role in food intake regulation. We show that expression of ATP6v0a1, a subunit of V-ATPase, is significantly induced in both obese mouse and human adipocytes that persists after weight loss. C. elegans mutants deficient in Atp6v0A1/unc32 eat less than WT controls. Adipocyte-specific Atp6v0a1 knockout mice have reduced food intake and gain less weight in response to HFD. Pharmacological disruption of V-ATPase assembly leads to decreased food intake and less weight re-gain. In summary, using a series of genetic tools from invertebrates to vertebrates, we identify ATP6v0a1 as a regulator of peripheral metabolic memory, providing a potential target for regulation of food intake, weight loss maintenance and the treatment of obesity. |
| 巻・号 | 13(1) |
| ページ | 5092 |
| 公開日 | 2022-8-30 |
| DOI | 10.1038/s41467-022-32764-5 |
| PII | 10.1038/s41467-022-32764-5 |
| PMID | 36042358 |
| PMC | PMC9427743 |
| MeSH | Adipocytes / metabolism Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism Diet, High-Fat* / adverse effects Eating / physiology Humans Mice Mice, Inbred C57BL Mice, Obese Obesity* / genetics Obesity* / metabolism Vacuolar Proton-Translocating ATPases / genetics Vacuolar Proton-Translocating ATPases / metabolism* Weight Gain Weight Loss |
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オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 24 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm5764 tm6310 |