論文 - 詳細
| RRC ID | 76340 |
|---|---|
| 著者 | Zhang X, Liu J, Pan T, Ward A, Liu J, Xu XZS. |
| タイトル | A cilia-independent function of BBSome mediated by DLK-MAPK signaling in C. elegans photosensation. |
| ジャーナル | Dev Cell |
| Abstract |
Bardet-Biedl syndrome (BBS) is a genetic disorder that affects primary cilia. BBSome, a protein complex composed of eight BBS proteins, regulates the structure and function of cilia, and its malfunction causes BBS in humans. Here, we report a cilia-independent function of BBSome. To identify genes that regulate the C. elegans photoreceptor protein LITE-1 in ciliated ASH photosensory neurons, we performed a genetic screen and isolated bbs mutants. Functional analysis revealed that BBSome regulates LITE-1 protein stability independently of cilia. Through another round of genetic screening, we found that this cilia-independent function of BBSome is mediated by DLK-MAPK signaling, which acts downstream of BBSome to control LITE-1 stability via Rab5-mediated endocytosis. BBSome exerts its function by regulating the expression of DLK. BBSome also regulates the expression of LZK, a mammalian DLK in human cells. These studies identify a cilia-independent function of BBSome and uncover DLK as an evolutionarily conserved BBSome effector. |
| 巻・号 | 57(12) |
| ページ | 1545-1557.e4 |
| 公開日 | 2022-6-20 |
| DOI | 10.1016/j.devcel.2022.05.005 |
| PII | S1534-5807(22)00333-1 |
| PMID | 35649417 |
| PMC | PMC9233093 |
| MeSH | Animals Bardet-Biedl Syndrome* / genetics Bardet-Biedl Syndrome* / metabolism Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism Cilia* / metabolism Humans Mammals / metabolism Protein Transport / genetics Proteins / metabolism |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 20 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 3.0 |
| リソース情報 | |
| 線虫 | tm3038 tm324 |