論文 - 詳細
| RRC ID | 76348 |
|---|---|
| 著者 | Zhu J, Meng W, Lam SM, Shui G, Huang X. |
| タイトル | Phosphatidylcholine deficiency increases ferroptosis susceptibility in the Caenorhabditis elegans germline. |
| ジャーナル | J Genet Genomics |
| Abstract |
Ferroptosis, a regulated and iron-dependent form of cell death characterized by peroxidation of membrane phospholipids, has tremendous potential for the therapy of human diseases. The causal link between phospholipid homeostasis and ferroptosis is incompletely understood. Here, we reveal that spin-4, a previously identified regulator of the "B12-one-carbon cycle-phosphatidylcholine (PC)" pathway, sustains germline development and fertility by ensuring PC sufficiency in the nematode Caenorhabditis elegans. Mechanistically, SPIN-4 regulates lysosomal activity which is required for B12-associated PC synthesis. PC deficiency-induced sterility can be rescued by reducing the levels of polyunsaturated fatty acids, reactive oxygen species, and redox-active iron, which indicates that the sterility is mediated by germline ferroptosis. These results highlight the critical role of PC homeostasis in ferroptosis susceptibility and offer a new target for pharmacological approaches. |
| 巻・号 | 50(5) |
| ページ | 318-329 |
| 公開日 | 2023-5-1 |
| DOI | 10.1016/j.jgg.2023.03.005 |
| PII | S1673-8527(23)00069-3 |
| PMID | 36933794 |
| MeSH | Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism Ferroptosis* / genetics Germ Cells / metabolism Humans Infertility* Iron / metabolism Phosphatidylcholines |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm5842 |