| RRC ID |
76365
|
| Author |
Kurakado S, Matsumoto Y, Sugita T.
|
| Title |
Efficacy of Posaconazole against Rhizopus oryzae Infection in Silkworm.
|
| Journal |
Med Mycol J
|
| Abstract |
Rhizopus oryzae causes fatal invasive mucormycosis, especially in immunocompromised patients. Posaconazole is used to treat mucormycosis caused by R. oryzae, which is resistant to fluconazole and voriconazole. We evaluated the efficacy of posaconazole against R. oryzae in vivo using a silkworm infection model at 37℃, the human body temperature. The level of pathogenicity differed among the R. oryzae isolates, and posaconazole prolonged the survival of infected silkworms. Therefore, the silkworm infection model is suitable for investigating the virulence factors of R. oryzae and developing antifungal agents for mucormycosis.
|
| Volume |
62(3)
|
| Pages |
53-57
|
| Published |
2021-1-1
|
| DOI |
10.3314/mmj.21-00004
|
| PMID |
34471035
|
| MeSH |
Animals
Antifungal Agents / pharmacology
Antifungal Agents / therapeutic use
Bombyx*
Humans
Mucormycosis* / drug therapy
Rhizopus
Rhizopus oryzae
Triazoles
|
| Resource |
| Pathogenic eukaryotic microorganisms |
Rhizopus oryzae IFM 40515, IFM 46105, IFM 58016, IFM 58315, IFM 58330, IFM 61553, IFM 62149, IFM 62202, IFM 62923, IFM 63436, IFM 64256 |
