Reference - Detail
| RRC ID | 76368 |
|---|---|
| Author | Sugimoto C, Murakami Y, Ishii E, Fujita H, Wakao H. |
| Title | Reprogramming and redifferentiation of mucosal-associated invariant T cells reveal tumor inhibitory activity. |
| Journal | Elife |
| Abstract |
Mucosal-associated invariant T (MAIT) cells belong to a family of innate-like T cells that bridge innate and adaptive immunities. Although MAIT cells have been implicated in tumor immunity, it currently remains unclear whether they function as tumor-promoting or inhibitory cells. Therefore, we herein used induced pluripotent stem cell (iPSC) technology to investigate this issue. Murine MAIT cells were reprogrammed into iPSCs and redifferentiated towards MAIT-like cells (m-reMAIT cells). m-reMAIT cells were activated by an agonist in the presence and absence of antigen-presenting cells and MR1-tetramer, a reagent to detect MAIT cells. This activation accompanied protein tyrosine phosphorylation and the production of T helper (Th)1, Th2, and Th17 cytokines and inflammatory chemokines. Upon adoptive transfer, m-reMAIT cells migrated to different organs with maturation in mice. Furthermore, m-reMAIT cells inhibited tumor growth in the lung metastasis model and prolonged mouse survival upon tumor inoculation through the NK cell-mediated reinforcement of cytolytic activity. Collectively, the present results demonstrated the utility and role of m-reMAIT cells in tumor immunity and provide insights into the function of MAIT cells in immunity. |
| Volume | 11 |
| Published | 2022-4-5 |
| DOI | 10.7554/eLife.70848 |
| PII | 70848 |
| PMID | 35379387 |
| PMC | PMC8983048 |
| MeSH | Adaptive Immunity Animals Induced Pluripotent Stem Cells* / metabolism Lung Neoplasms* / metabolism Mice Mucosal-Associated Invariant T Cells* Mucous Membrane |
| IF | 7.08 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 11 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | LLC(RCB0558) EL4(RCB1641) RL♂1(Gloria)(RCB2784) YAC-1(RCB1165) |