RRC ID 76415
Author Tsuji M, Taira H, Udagawa T, Aoki T, Hirayama T, Nagasawa H.
Title Synthesis and photochemical properties of caged peroxides for photocontrol of cellular oxidative stress.
Journal Chem Commun (Camb)
Abstract We developed a caged hydroperoxide, BhcTBHP, releasing prooxidant TBHP under blue light irradiation. MitoTBHP with triphenylphosphonium at position 7 triggered selective oxidative stress and membrane depolarization in mitochondria upon photoirradiation. This study presents a powerful tool for studying redox signaling and oxidative stress in living cells.
Volume 59(44)
Pages 6706-6709
Published 2023-5-30
DOI 10.1039/d3cc01192e
PMID 37190960
MeSH Hydrogen Peroxide Oxidation-Reduction Oxidative Stress* Peroxides* / pharmacology Reactive Oxygen Species tert-Butylhydroperoxide / pharmacology
IF 5.996
Human and Animal Cells MCF7(RCB1904)