論文 - 詳細
| RRC ID | 76439 |
|---|---|
| 著者 | Kaizuka Y, Machida R. |
| タイトル | Antiviral Activity of Cell Membrane-Bound Amphiphilic Polymers. |
| ジャーナル | Langmuir |
| Abstract |
We demonstrate that cholesterol-modified polyethylene glycol has antiviral activity, exerted by anchoring to plasma membranes and sterically inhibiting viruses from entering cells. These polymers distribute sparsely on cell membranes even at binding saturation. However, the polymers have sufficient elastic repulsion energy to repel various kinds of viruses with sizes larger than the mean distances between anchored polymers, including SARS-CoV-2 pseudoparticles. Our strategy can be applied to protect the epithelium from viruses. When these polymers are applied to the epithelium, they localize on the apical surface due to the tight junction barriers, resulting in surface-only coating. Therefore, these polymers can prevent the entry of viruses into cells of the epithelium with minimal disturbance to lateral cell-cell interactions and organizations. |
| 巻・号 | 39(15) |
| ページ | 5408-5417 |
| 公開日 | 2023-4-18 |
| DOI | 10.1021/acs.langmuir.3c00054 |
| PMID | 37014318 |
| PMC | PMC10081831 |
| MeSH | Antiviral Agents / pharmacology COVID-19* Cell Membrane Humans Polymers* / pharmacology SARS-CoV-2 |
| IF | 3.557 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 遺伝子材料 | AxCAEGFP (forward) (RDB03343) pCMV-VSV-G-RSV-Rev (RDB04393) pCAG-HIVgp (RDB04394) |