論文 - 詳細
| RRC ID | 76457 |
|---|---|
| 著者 | Tran LS, Ying L, D'Costa K, Wray-McCann G, Kerr G, Le L, Allison CC, Ferrand J, Chaudhry H, Emery J, De Paoli A, Colon N, Creed S, Kaparakis-Liaskos M, Como J, Dowling JK, Johanesen PA, Kufer TA, Pedersen JS, Mansell A, Philpott DJ, Elgass KD, Abud HE, Nachbur U, Croker BA, Masters SL, Ferrero RL. |
| タイトル | NOD1 mediates interleukin-18 processing in epithelial cells responding to Helicobacter pylori infection in mice. |
| ジャーナル | Nat Commun |
| Abstract |
The interleukin-1 family members, IL-1β and IL-18, are processed into their biologically active forms by multi-protein complexes, known as inflammasomes. Although the inflammasome pathways that mediate IL-1β processing in myeloid cells have been defined, those involved in IL-18 processing, particularly in non-myeloid cells, are still not well understood. Here we report that the host defence molecule NOD1 regulates IL-18 processing in mouse epithelial cells in response to the mucosal pathogen, Helicobacter pylori. Specifically, NOD1 in epithelial cells mediates IL-18 processing and maturation via interactions with caspase-1, instead of the canonical inflammasome pathway involving RIPK2, NF-κB, NLRP3 and ASC. NOD1 activation and IL-18 then help maintain epithelial homoeostasis to mediate protection against pre-neoplastic changes induced by gastric H. pylori infection in vivo. Our findings thus demonstrate a function for NOD1 in epithelial cell production of bioactive IL-18 and protection against H. pylori-induced pathology. |
| 巻・号 | 14(1) |
| ページ | 3804 |
| 公開日 | 2023-6-26 |
| DOI | 10.1038/s41467-023-39487-1 |
| PII | 10.1038/s41467-023-39487-1 |
| PMID | 37365163 |
| PMC | PMC10293252 |
| MeSH | Animals Epithelial Cells* / metabolism Helicobacter Infections* / metabolism Helicobacter pylori Inflammasomes / metabolism Interleukin-18* / metabolism Interleukin-1beta / metabolism Mice NLR Family, Pyrin Domain-Containing 3 Protein / metabolism Nod1 Signaling Adaptor Protein* / metabolism Signal Transduction |
| IF | 12.121 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 18 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | GSM06(RCB1779) |