| RRC ID |
76509
|
| Author |
Quiñonez-Silvero C, Hübner K, Herzog W.
|
| Title |
Development of the brain vasculature and the blood-brain barrier in zebrafish.
|
| Journal |
Dev Biol
|
| Abstract |
To ensure tissue homeostasis the brain needs to be protected from blood-derived fluctuations or pathogens that could affect its function. Therefore, the brain capillaries develop tissue-specific properties to form a selective blood-brain barrier (BBB), allowing the passage of essential molecules to the brain and blocking the penetration of potentially harmful compounds or cells. Previous studies reported the presence of this barrier in zebrafish. The intrinsic features of the zebrafish embryos and larvae in combination with optical techniques, make them suitable for the study of barrier establishment and maturation. In this review, we discuss the most recent contributions to the development and formation of a functional zebrafish BBB. Moreover, we compare the molecular and cellular characteristic of the zebrafish and the mammalian BBB.
|
| Volume |
457(2)
|
| Pages |
181-190
|
| Published |
2020-1-15
|
| DOI |
10.1016/j.ydbio.2019.03.005
|
| PII |
S0012-1606(18)30784-X
|
| PMID |
30862465
|
| MeSH |
Animals
Blood-Brain Barrier / embryology*
Brain / blood supply*
Brain / embryology
Cardiovascular System / embryology*
Endothelial Cells / physiology
Endothelium, Vascular / embryology
Endothelium, Vascular / physiology
Neovascularization, Physiologic / physiology*
Tight Junctions / physiology
Zebrafish / embryology*
|
| IF |
2.896
|
| Resource |
| Zebrafish |
UAS:GFP |
