| RRC ID |
76661
|
| 著者 |
Jack R. Davison, Rahim Rajwani, Gengxiang Zhao, Carole A. Bewley
|
| タイトル |
The genome of antibiotic-producing colonies of the Pelagophyte alga Chrysophaeum taylorii reveals a diverse and non-canonical capacity for secondary metabolism
|
| ジャーナル |
Scientific Reports
|
| Abstract |
Chrysophaeum taylorii is a member of an understudied clade of marine algae that can be responsible for harmful coastal blooms and is known to accumulate bioactive natural products including antibiotics of the chrysophaentin class. Whole genome sequencing of laboratory-cultivated samples revealed an extensive and diverse complement of secondary metabolite biosynthetic genes in C. taylorii, alongside a small microbiome with a more limited biosynthetic potential. 16S microbiome analysis of laboratory cultured alongside wild-collected samples revealed several common taxa; however, analysis of biosynthetic genes suggested an algal origin for the chrysophaentins, possibly via one of several non-canonical polyketide synthase genes encoded within the genome.
|
| 巻・号 |
13
|
| 公開日 |
2023-7-24
|
| DOI |
10.1038/s41598-023-38042-8
|
| PMID |
37488207
|
| PMC |
PMC10366177
|
| MeSH |
Anti-Bacterial Agents
Biological Products*
Laboratories
Microbiota*
Secondary Metabolism
|
| IF |
3.998
|
| リソース情報 |
| 藻類 |
NIES-1699 |
