論文 - 詳細
| RRC ID | 76828 |
|---|---|
| 著者 | Han Y, Tomita T, Kato M, Ashihara N, Higuchi Y, Matoba H, Wang W, Hayashi H, Itoh Y, Takahashi S, Kurita H, Nakayama J, Okumura N, Hiratsuka S. |
| タイトル | Citrullinated fibrinogen-SAAs complex causes vascular metastagenesis. |
| ジャーナル | Nat Commun |
| Abstract |
Primary tumor cells metastasize to a distant preferred organ. However, the most decisive host factors that determine the precise locations of metastases in cancer patients remain unknown. We have demonstrated that post-translational citrullination of fibrinogen creates a metastatic niche in the vulnerable spots. Pulmonary endothelial cells mediate the citrullination of fibrinogen, changing its conformation, surface charge, and binding properties with serum amyloid A proteins (SAAs), to make it a host tissue-derived metastatic pathogen. The human-specific SAAs-citrullinated fibrinogen (CitFbg) complex recruits cancer cells to form a protein-metastatic cell aggregation in humanized SAA cluster mice. Furthermore, a CitFbg peptide works as a competitive inhibitor to block the homing of metastatic cells into the SAAs-CitFbg sites. The potential metastatic sites in the lungs of patients are clearly visualized by our specific antibody for CitFbg. Thus, CitFbg deposition displays metastatic risks for cancer patients, and the citrullinated peptide is a new type of metastasis inhibitor. |
| 巻・号 | 14(1) |
| ページ | 4960 |
| 公開日 | 2023-8-24 |
| DOI | 10.1038/s41467-023-40371-1 |
| PII | 10.1038/s41467-023-40371-1 |
| PMID | 37620307 |
| PMC | PMC10449786 |
| MeSH | Animals Causality Endothelial Cells* Fibrinogen Hemostatics* Humans Mice Serum Amyloid A Protein |
| IF | 12.121 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 8 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | LLC(RCB0558) |