論文 - 詳細
| RRC ID | 76840 |
|---|---|
| 著者 | Tajiri R, Hirano A, Kaibara YY, Tezuka D, Chen Z, Kojima T. |
| タイトル | Notch signaling generates the "cut here line" on the cuticle of the puparium in Drosophila melanogaster. |
| ジャーナル | iScience |
| Abstract |
During a molt or eclosion, insects shed their cuticle, an extracellular matrix made by underlying epidermal cells, by cleavage along a defined line. This means that the "cut here line" is pre-formed on the cuticle, and its formation is indispensable for insect life. Here, we show that the proper formation of the operculum ridge (OR), which is the "cut here line" on the puparium (pupal case) of Drosophila melanogaster, involves Notch signaling activation in the epidermal cells just beneath the future OR region (OR-forming cells). The inhibition of Notch signaling causes defects in eclosion due to failure in OR cleavage, the chitin organization and several cuticular proteins localization, glucose dehydrogenase (Gld) activity, and OR-forming cell shape. Our findings provide the first insight into the molecular basis of the structure and formation of the "cut here line" on the cuticle. |
| 巻・号 | 26(8) |
| ページ | 107279 |
| 公開日 | 2023-8-18 |
| DOI | 10.1016/j.isci.2023.107279 |
| PII | S2589-0042(23)01356-1 |
| PMID | 37529108 |
| PMC | PMC10387574 |
| IF | 4.447 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | GL00092 DGRC#107727 DGRC#108439 DGRC#106364 DGRC#107388 DGRC#110658 |