論文 - 詳細
| RRC ID | 76845 |
|---|---|
| 著者 | Endo I, Amatya VJ, Kushitani K, Kambara T, Nakagiri T, Aoe K, Takeshima Y. |
| タイトル | FOXM1 Promotes Mesothelioma Cell Migration and Invasion via Activation of SMAD Signaling. |
| ジャーナル | Anticancer Res |
| Abstract |
BACKGROUND/AIM:Forkhead box M1 (FOXM1) is a transcription factor closely associated with various human malignancies and is considered an attractive target for cancer therapy. Mesothelioma is a malignancy primarily due to asbestos exposure and certain genetic factors, requiring a better understanding of tumorigenesis for improved treatment. Asbestos-exposed human mesothelial cells have been reported to up-regulate FOXM1 expression in a dose-dependent manner. MATERIALS AND METHODS:FOXM1 expression was evaluated in mesothelioma tissues and cell lines. FOXM1 small interfering RNA was transfected into mesothelioma cell lines to analyze its biological functions and regulatory mechanisms. RESULTS:FOXM1 was over-expressed in mesothelioma tissues and cell lines. Knock-down of FOXM1 in mesothelioma cell lines inhibited cell proliferation, migration, and invasion. These results suggest that up-regulation of FOXM1 expression promotes mesothelioma tumorigenesis and progression. We previously reported that insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) promotes the proliferation, migration, and invasion of mesothelioma cell lines. In this study, IGF2BP3 knock-down suppressed FOXM1 expression in mesothelioma cell lines. Our results suggest that IGF2BP3, an upstream regulator, contributes to increased FOXM1 expression. Furthermore, IGF2BP3 and FOXM1 knock-down suppressed SMAD signaling by inhibiting SMAD2/3 phosphorylation in mesothelioma cell lines. CONCLUSION:IGF2BP3/FOXM1 promotes mesothelioma cell migration and invasion via SMAD signaling, highlighting IGF2BP3/FOXM1 as a potential target for mesothelioma treatment. |
| 巻・号 | 43(9) |
| ページ | 3961-3968 |
| 公開日 | 2023-9-1 |
| DOI | 10.21873/anticanres.16583 |
| PII | 43/9/3961 |
| PMID | 37648326 |
| MeSH | Carcinogenesis Cell Movement Cell Transformation, Neoplastic Forkhead Box Protein M1 / genetics Humans Mesothelioma* / genetics Mesothelioma, Malignant* |
| IF | 1.994 |
| リソース情報 | |
| ヒト・動物細胞 | ACC-MESO-1(RCB2292) |