論文 - 詳細
| RRC ID | 76858 |
|---|---|
| 著者 | Watanabe M, Sofuni T, Nohmi T. |
| タイトル | Comparison of the sensitivity of Salmonella typhimurium strains YG1024 and YG1012 for detecting the mutagenicity of aromatic amines and nitroarenes. |
| ジャーナル | Mutat Res |
| Abstract |
Salmonella typhimurium YG1024 is a derivative of S. typhimurium TA98 with a high level of N-hydroxyarylamine O-acetyltransferase (OAT) activity. We have demonstrated that this strain is highly sensitive to the mutagenic actions of N-hydroxyarylamines derived from aromatic amines and nitroarenes. In this paper, we compared the sensitivities of YG1024 with those of S. typhimurium YG1012, which has about 4 times higher OAT activity than YG1024 but lacks plasmid pKM101. It turned out that YG1024 was more sensitive to the mutagenic actions of 1-aminonaphthalene, 1-nitropyrene, 1,8-dinitropyrene and 2-nitronaphthalene than YG1012 and showed comparable sensitivity to 2-hydroxy-acetylaminofluorene, 2-aminoanthracene and 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole (Glu-P-1) to YG1012. These results suggested that YG1024 is more suitable than YG1012 for the efficient detection of mutagenic aromatic amines and nitroarenes. |
| 巻・号 | 301(1) |
| ページ | 7-12 |
| 公開日 | 1993-1-1 |
| DOI | 10.1016/0165-7992(93)90049-2 |
| PII | 0165-7992(93)90049-2 |
| PMID | 7677947 |
| MeSH | 1-Naphthylamine / toxicity 4-Nitroquinoline-1-oxide / toxicity Acetyltransferases* Acyltransferases / metabolism Amines / toxicity* Anthracenes / toxicity Cloning, Molecular Environmental Pollutants / toxicity Frameshift Mutation Hydroxyacetylaminofluorene / toxicity Hydroxylamines / toxicity* Imidazoles / toxicity Microbial Sensitivity Tests Mutagenicity Tests* Mutagens* Naphthalenes / toxicity Nitro Compounds / toxicity* Plasmids Pyrenes / toxicity Salmonella typhimurium / drug effects* Salmonella typhimurium / enzymology Salmonella typhimurium / genetics* Species Specificity |
| IF | 2.463 |
| リソース情報 | |
| 原核生物(大腸菌) | ME10027 |