論文 - 詳細
| RRC ID | 76859 |
|---|---|
| 著者 | Hagiwara Y, Watanabe M, Oda Y, Sofuni T, Nohmi T. |
| タイトル | Specificity and sensitivity of Salmonella typhimurium YG1041 and YG1042 strains possessing elevated levels of both nitroreductase and acetyltransferase activity. |
| ジャーナル | Mutat Res |
| Abstract |
Acetyltransferase and nitroreductase are enzymes involved in the intracellular metabolic activation of nitroarenes and/or aromatic amines in Salmonella typhimurium. The plasmid carrying both the acetyltransferase and nitroreductase genes was introduced into S. typhimurium TA98 and TA100. The resulting strains, YG1041 and YG1042, respectively, showed high levels of both enzyme activities and were more sensitive to the mutagenic action of some nitro-aromatic compounds such as 2-nitrofluorene, 1-nitropyrene and p-nitrophenetole than did the sensitive strains previously established in this laboratory or the conventional strains. These results indicate that the new strains permit the very efficient detection of the mutagenicity of nitroarenes in the environment. |
| 巻・号 | 291(3) |
| ページ | 171-80 |
| 公開日 | 1993-6-1 |
| DOI | 10.1016/0165-1161(93)90157-u |
| PII | 0165-1161(93)90157-U |
| PMID | 7685058 |
| MeSH | Acetyltransferases / genetics Acetyltransferases / metabolism* Biotransformation Fluorenes / toxicity Mutagenicity Tests* Mutagens / toxicity Nitrobenzenes / toxicity Nitroreductases / genetics Nitroreductases / metabolism* Pyrenes / toxicity Salmonella typhimurium / drug effects* Salmonella typhimurium / enzymology Sensitivity and Specificity |
| IF | 2.463 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Policy sources |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 原核生物(大腸菌) | ME10032 ME10033 |