| RRC ID |
76915
|
| 著者 |
Saavedra P, Dumesic PA, Hu Y, Filine E, Jouandin P, Binari R, Wilensky SE, Rodiger J, Wang H, Chen W, Liu Y, Spiegelman BM, Perrimon N.
|
| タイトル |
REPTOR and CREBRF encode key regulators of muscle energy metabolism.
|
| ジャーナル |
Nat Commun
|
| Abstract |
Metabolic flexibility of muscle tissue describes the adaptive capacity to use different energy substrates according to their availability. The disruption of this ability associates with metabolic disease. Here, using a Drosophila model of systemic metabolic dysfunction triggered by yorkie-induced gut tumors, we show that the transcription factor REPTOR is an important regulator of energy metabolism in muscles. We present evidence that REPTOR is activated in muscles of adult flies with gut yorkie-tumors, where it modulates glucose metabolism. Further, in vivo studies indicate that sustained activity of REPTOR is sufficient in wildtype muscles to repress glycolysis and increase tricarboxylic acid (TCA) cycle metabolites. Consistent with the fly studies, higher levels of CREBRF, the mammalian ortholog of REPTOR, reduce glycolysis in mouse myotubes while promoting oxidative metabolism. Altogether, our results define a conserved function for REPTOR and CREBRF as key regulators of muscle energy metabolism.
|
| 巻・号 |
14(1)
|
| ページ |
4943
|
| 公開日 |
2023-8-15
|
| DOI |
10.1038/s41467-023-40595-1
|
| PII |
10.1038/s41467-023-40595-1
|
| PMID |
37582831
|
| PMC |
PMC10427696
|
| MeSH |
Animals
Citric Acid Cycle / physiology
Drosophila*
Drosophila Proteins* / genetics
Energy Metabolism*
Glycolysis
Mice
Muscles / metabolism
Neoplasms / metabolism
Transcription Factors* / genetics
Tumor Suppressor Proteins* / genetics
|
| IF |
12.121
|
| リソース情報 |
| ショウジョウバエ |
15009R-3
13624R-3 |
