論文 - 詳細
| RRC ID | 77001 |
|---|---|
| 著者 | Donaldson PD, Navabi ZS, Carter RE, Fausner SML, Ghanbari L, Ebner TJ, Swisher SL, Kodandaramaiah SB. |
| タイトル | Polymer Skulls With Integrated Transparent Electrode Arrays for Cortex-Wide Opto-Electrophysiological Recordings. |
| ジャーナル | Adv Healthc Mater |
| Abstract |
Electrophysiology and optical imaging provide complementary neural sensing capabilities - electrophysiological recordings have high temporal resolution, while optical imaging allows recording of genetically-defined populations at high spatial resolution. Combining these two modalities for simultaneous large-scale, multimodal sensing of neural activity across multiple brain regions can be very powerful. Here, transparent, inkjet-printed electrode arrays with outstanding optical and electrical properties are seamlessly integrated with morphologically conformant transparent polymer skulls. Implanted on transgenic mice expressing the Calcium (Ca2+ ) indicator GCaMP6f in excitatory neurons, these "eSee-Shells" provide a robust opto-electrophysiological interface for over 100 days. eSee-Shells enable simultaneous mesoscale Ca2+ imaging and electrocorticography (ECoG) acquisition from multiple brain regions covering 45 mm2 of cortex under anesthesia and in awake animals. The clarity and transparency of eSee-Shells allow recording single-cell Ca2+ signals directly below the electrodes and interconnects. Simultaneous multimodal measurement of cortical dynamics reveals changes in both ECoG and Ca2+ signals that depend on the behavioral state. |
| 巻・号 | 11(18) |
| ページ | e2200626 |
| 公開日 | 2022-9-1 |
| DOI | 10.1002/adhm.202200626 |
| PMID | 35869830 |
| PMC | PMC9573805 |
| MeSH | Animals Calcium* Electrodes, Implanted Electrophysiological Phenomena Mice Mice, Transgenic Polymers* Skull |
| IF | 7.367 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC09452 |