| RRC ID |
77001
|
| 著者 |
Donaldson PD, Navabi ZS, Carter RE, Fausner SML, Ghanbari L, Ebner TJ, Swisher SL, Kodandaramaiah SB.
|
| タイトル |
Polymer Skulls With Integrated Transparent Electrode Arrays for Cortex-Wide Opto-Electrophysiological Recordings.
|
| ジャーナル |
Adv Healthc Mater
|
| Abstract |
Electrophysiology and optical imaging provide complementary neural sensing capabilities - electrophysiological recordings have high temporal resolution, while optical imaging allows recording of genetically-defined populations at high spatial resolution. Combining these two modalities for simultaneous large-scale, multimodal sensing of neural activity across multiple brain regions can be very powerful. Here, transparent, inkjet-printed electrode arrays with outstanding optical and electrical properties are seamlessly integrated with morphologically conformant transparent polymer skulls. Implanted on transgenic mice expressing the Calcium (Ca2+ ) indicator GCaMP6f in excitatory neurons, these "eSee-Shells" provide a robust opto-electrophysiological interface for over 100 days. eSee-Shells enable simultaneous mesoscale Ca2+ imaging and electrocorticography (ECoG) acquisition from multiple brain regions covering 45 mm2 of cortex under anesthesia and in awake animals. The clarity and transparency of eSee-Shells allow recording single-cell Ca2+ signals directly below the electrodes and interconnects. Simultaneous multimodal measurement of cortical dynamics reveals changes in both ECoG and Ca2+ signals that depend on the behavioral state.
|
| 巻・号 |
11(18)
|
| ページ |
e2200626
|
| 公開日 |
2022-9-1
|
| DOI |
10.1002/adhm.202200626
|
| PMID |
35869830
|
| PMC |
PMC9573805
|
| MeSH |
Animals
Calcium*
Electrodes, Implanted
Electrophysiological Phenomena
Mice
Mice, Transgenic
Polymers*
Skull
|
| IF |
7.367
|
| リソース情報 |
| 実験動物マウス |
RBRC09452 |
