論文 - 詳細
| RRC ID | 77035 |
|---|---|
| 著者 | Viriyaadhammaa N, Saiai A, Neimkhum W, Nirachonkul W, Chaiyana W, Chiampanichayakul S, Tima S, Usuki T, Duangmano S, Anuchapreeda S. |
| タイトル | Cytotoxic and Antiproliferative Effects of Diarylheptanoids Isolated from Curcuma comosa Rhizomes on Leukaemic Cells. |
| ジャーナル | Molecules |
| Abstract |
Curcuma comosa belongs to the Zingiberaceae family. In this study, two natural compounds were isolated from C. comosa, and their structures were determined using nuclear magnetic resonance. The isolated compounds were identified as 7-(3,4-dihydroxyphenyl)-5-hydroxy-1-phenyl-(1E)-1-heptene (1) and trans-1,7-diphenyl-5-hydroxy-1-heptene (2). Compound 1 showed the strongest cytotoxicity effect against HL-60 cells, while its antioxidant and anti-inflammatory properties were stronger than those of compound 2. Compound 1 proved to be a potent antioxidant, compared to ascorbic acid. Neither compounds had any effect on red blood cell haemolysis. Furthermore, compound 1 significantly decreased Wilms' tumour 1 protein expression and cell proliferation in KG-1a cells. Compound 1 decreased the WT1 protein levels in a time- and dose- dependent manner. Compound 1 suppressed cell cycle at the S phase. In conclusion, compound 1 has a promising chemotherapeutic potential against leukaemia. |
| 巻・号 | 25(22) |
| 公開日 | 2020-11-23 |
| DOI | 10.3390/molecules25225476 |
| PII | molecules25225476 |
| PMID | 33238470 |
| PMC | PMC7700379 |
| MeSH | Animals Anti-Inflammatory Agents / chemistry Anti-Inflammatory Agents / isolation & purification Anti-Inflammatory Agents / pharmacology Antineoplastic Agents / chemistry* Antineoplastic Agents / isolation & purification Antineoplastic Agents / pharmacology* Antioxidants / chemistry Antioxidants / isolation & purification Antioxidants / pharmacology Cell Cycle / drug effects Cell Line, Tumor Cell Proliferation / drug effects Chromatography / methods Curcuma / chemistry* Diarylheptanoids / chemistry* Diarylheptanoids / isolation & purification Diarylheptanoids / pharmacology* Dose-Response Relationship, Drug Flow Cytometry Gene Expression Hemolysis Humans Leukemia / genetics Leukemia / metabolism Leukocytes, Mononuclear / drug effects Leukocytes, Mononuclear / metabolism Mice Molecular Structure Plant Extracts / chemistry* Plant Extracts / isolation & purification Plant Extracts / pharmacology* RAW 264.7 Cells Rhizome / chemistry* WT1 Proteins / genetics WT1 Proteins / metabolism |
| IF | 3.267 |
| リソース情報 | |
| ヒト・動物細胞 | K562(RCB1897) |