| RRC ID |
77196
|
| 著者 |
Thu NN, Mai TT, Trang TTT, Tuan NA, Quyen TC, Hanh NL, Hoan NH, Lan BTH, Hau PT, Tue HH, Dung TV, Tsuji R, Watanabe Y, Yamamoto N, Kanauchi O.
|
| タイトル |
Impact of Infectious Disease after Lactococcus lactis Strain Plasma Intake in Vietnamese Schoolchildren: A Randomized, Placebo-Controlled, Double-Blind Study.
|
| ジャーナル |
Nutrients
|
| Abstract |
Lactococcus lactis strain Plasma (LC-Plasma) is reported to have anti-viral effects via direct activation of plasmacytoid dendritic cells, which upregulate the production of type I and III interferons. A randomized, placebo-controlled, double-blind, parallel group study was designed for elementary schoolchildren, grades 1 to 3, in Vietnam. LC-Plasma or a control were administered to schoolchildren as a beverage (1.0 × 1011 count LC-Plasma/day/person). The primary endpoint was to determine the efficacy of LC-Plasma in reducing the cumulative days absent from school due to upper respiratory disease (URID) and gastrointestinal disease (GID), and the secondary endpoint was to evaluate the potency of LC-Plasma on URID/GID symptoms and general well-being scores. LC-Plasma intake significantly reduced the cumulative days absent from school due to URID/GID (Odds ratio (OR) = 0.57, p = 0.004) and URID alone (OR = 0.56, p = 0.005); LC-Plasma also significantly reduced the number of cumulative fever positive days during the first 4 weeks of intervention (OR = 0.58, p = 0.001) and cumulative days with diarrhea during the last 4 weeks of the intervention period (OR = 0.78, p = 0.01). The number of positive general wellbeing days was significantly improved in the LC-Plasma group compared with the control throughout the intervention period (OR = 0.93, 0.93, p = 0.03, 0.04 in the first and last 4 weeks of the intervention, respectively). These data suggest that LC-Plasma seems to improve the health condition of elementary schoolchildren and reduces school absenteeism due to infectious disease, especially URID.
|
| 巻・号 |
14(3)
|
| 公開日 |
2022-1-27
|
| DOI |
10.3390/nu14030552
|
| PII |
nu14030552
|
| PMID |
35276914
|
| PMC |
PMC8839753
|
| MeSH |
Asian People
Child
Communicable Diseases*
Double-Blind Method
Humans
Lactococcus lactis* / physiology
Vietnam / epidemiology
|
| IF |
4.546
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| リソース情報 |
| 一般微生物 |
JCM 5805 |
