| RRC ID |
77205
|
| 著者 |
Andersen FD, Pedersen KD, Wilkens Juhl D, Mygind T, Chopin P, B Svenningsen E, Poulsen TB, Braad Lund M, Schramm A, Gotfredsen CH, Tørring T.
|
| タイトル |
Triculamin: An Unusual Lasso Peptide with Potent Antimycobacterial Activity.
|
| ジャーナル |
J Nat Prod
|
| Abstract |
Lasso peptides are ribosomally synthesized and post-translationally modified peptides (RiPPs) produced by microorganisms. Here we show that the two natural products triculamin and alboverticillin, originally isolated in 1967 and 1958, respectively, with potent and specific activity against mycobacteria are in fact the same lasso peptide. We solved the structure using 2D NMR spectroscopy and expanded on the previously reported bioactivity. Through genome sequencing, we identify the responsible biosynthetic gene clusters, which curiously revealed that, unlike any known lasso peptides, their precursor peptides appear to have a follower instead of a leader peptide.
|
| 巻・号 |
85(6)
|
| ページ |
1514-1521
|
| 公開日 |
2022-6-24
|
| DOI |
10.1021/acs.jnatprod.2c00065
|
| PMID |
35748039
|
| MeSH |
Biological Products*
Multigene Family
Peptides / chemistry
Protein Processing, Post-Translational*
|
| IF |
3.782
|
| リソース情報 |
| 一般微生物 |
JCM 4242 |
