Reference - Detail
| RRC ID | 77218 |
|---|---|
| Author | Liu Y, Ding L, He J, Zhang Z, Deng Y, He S, Yan X. |
| Title | A new antibacterial chromone from a marine sponge-associated fungus Aspergillus sp. LS57. |
| Journal | Fitoterapia |
| Abstract |
Chemical investigation for the secondary metabolite of marine-derived fungus Aspergillus sp. LS57 resulted in the isolation of one new chromone named aspergilluone A (1) containing a chromone skeleton fused with an unusual hydrogenation cyclopentanoid ring, along with three known compounds 2-4. The structure of 1 was elucidated by 1D and 2D nuclear magnetic resonance (NMR) spectroscopic and mass spectrometric analyses. Its absolute configuration was established by combining NMR quantum chemical calculations and comparison between the experimental and calculated circular dichroism (CD) curves. Additionally, the antibacterial assay of compound 1 was performed. As a result, compound 1 showed in vitro anti-Mycobacterium tuberculosis with MIC value of 32 μg/mL, together with moderate antibacterial activity against Staphylococcus aureus (MIC values = 64 μg/mL), and exhibited feeble activity against gram-positive Bacillus subtilis and gram-negative pathogen Escherichia coli (both MICs = 128 μg/mL). |
| Volume | 154 |
| Pages | 105004 |
| Published | 2021-10-1 |
| DOI | 10.1016/j.fitote.2021.105004 |
| PII | S0367-326X(21)00179-9 |
| PMID | 34339802 |
| MeSH | Animals Anti-Bacterial Agents / isolation & purification Anti-Bacterial Agents / pharmacology* Aspergillus / chemistry* China Chromones / isolation & purification Chromones / pharmacology* Microbial Sensitivity Tests Molecular Structure Porifera / microbiology* |
| IF | 2.527 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| General Microbes | JCM 1465, JCM 1649 |