論文 - 詳細
| RRC ID | 77285 |
|---|---|
| 著者 | Kuriyama S, Tanaka M. |
| タイトル | Characteristic tetraspanin expression patterns mark various tissues during early Xenopus development. |
| ジャーナル | Dev Growth Differ |
| Abstract |
The tetraspanins (Tspans) constitute a family of cell surface proteins with four transmembrane domains. Tspans have been found on the plasma membrane and on exosomes of various organelles. Reports on the function of Tspans during the early development of Xenopus have mainly focused on the expression of uroplakins in gametes. Although the roles of extracellular vesicles (EVs) including exosomes have been actively analyzed in cancer research, the contribution of EVs to early development is not well understood. This is because the diffusivity of EVs is not compatible with a very strict developmental process. In this study, we analyzed members of the Tspan family in early development of Xenopus. Expression was prominent in specific organs such as the notochord, eye, cranial neural crest cells (CNCs), trunk neural crest cells, placodes, and somites. We overexpressed several combinations of Tspans in CNCs in vitro and in vivo. Changing the partner changed the distribution of fluorescent-labeled Tspans. Therefore, it is suggested that expression of multiple Tspans in a particular tissue might produce heterogeneity of intercellular communication, which has not yet been recognized. |
| 巻・号 | 65(2) |
| ページ | 109-119 |
| 公開日 | 2023-2-1 |
| DOI | 10.1111/dgd.12836 |
| PMID | 36606534 |
| MeSH | Animals Neural Crest* / metabolism Somites / metabolism Tetraspanins* / metabolism Xenopus laevis / metabolism |
| IF | 1.723 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ツメガエル・イモリ | Xenopus tropicalis |