論文 - 詳細
| RRC ID | 77316 |
|---|---|
| 著者 | Tsuna M, Kageyama S, Fukuoka J, Kitano H, Doki Y, Tezuka H, Yasuda H. |
| タイトル | Significance of S100A4 as a prognostic marker of lung squamous cell carcinoma. |
| ジャーナル | Anticancer Res |
| Abstract |
BACKGROUND:The prognostic significance of S100A as potential biomarker for breast cancer was reported; however, this finding has recently been challenged. Here, the aim was to assess whether S100A4 could also be a prognostic biomarker of lung cancer. MATERIALS AND METHODS:A specific high-titer anti-S100A4 monoclonal antibody was developed. The utility and specificity of this antibody was validated by immunostaining experiments. The antibody was tested against a newly developed high-density tissue microarray including 400 lung cancer tissues to examine the clinico-pathological and prognostic significance of S100A4 in lung cancer. RESULTS:The staining of S100A4 was significantly associated with patients' poor prognosis in lung squamous cell carcinoma but not lung adenocarcinoma. CONCLUSION:S100A4 seems to be a prognostic biomarker of lung squamous cell carcinoma (5-year survival rate of 38.5% versus 7.4%, p<0.01), but not of adenocarcinoma. |
| 巻・号 | 29(7) |
| ページ | 2547-54 |
| 公開日 | 2009-7-1 |
| PII | 29/7/2547 |
| PMID | 19596927 |
| MeSH | Base Sequence Biomarkers, Tumor / metabolism* Carcinoma, Squamous Cell / metabolism Carcinoma, Squamous Cell / pathology* DNA Primers Female Humans Immunohistochemistry Lung Neoplasms / metabolism Lung Neoplasms / pathology* Male Middle Aged S100 Calcium-Binding Protein A4 S100 Proteins / metabolism* Survival Rate |
| IF | 1.994 |
| リソース情報 | |
| ヒト・動物細胞 | WI-38(RCB0702) MDA-MB-453(RCB1192) |