RRC ID 77316
Author Tsuna M, Kageyama S, Fukuoka J, Kitano H, Doki Y, Tezuka H, Yasuda H.
Title Significance of S100A4 as a prognostic marker of lung squamous cell carcinoma.
Journal Anticancer Res
Abstract BACKGROUND:The prognostic significance of S100A as potential biomarker for breast cancer was reported; however, this finding has recently been challenged. Here, the aim was to assess whether S100A4 could also be a prognostic biomarker of lung cancer.
MATERIALS AND METHODS:A specific high-titer anti-S100A4 monoclonal antibody was developed. The utility and specificity of this antibody was validated by immunostaining experiments. The antibody was tested against a newly developed high-density tissue microarray including 400 lung cancer tissues to examine the clinico-pathological and prognostic significance of S100A4 in lung cancer.
RESULTS:The staining of S100A4 was significantly associated with patients' poor prognosis in lung squamous cell carcinoma but not lung adenocarcinoma.
CONCLUSION:S100A4 seems to be a prognostic biomarker of lung squamous cell carcinoma (5-year survival rate of 38.5% versus 7.4%, p<0.01), but not of adenocarcinoma.
Volume 29(7)
Pages 2547-54
Published 2009-7-1
PII 29/7/2547
PMID 19596927
MeSH Base Sequence Biomarkers, Tumor / metabolism* Carcinoma, Squamous Cell / metabolism Carcinoma, Squamous Cell / pathology* DNA Primers Female Humans Immunohistochemistry Lung Neoplasms / metabolism Lung Neoplasms / pathology* Male Middle Aged S100 Calcium-Binding Protein A4 S100 Proteins / metabolism* Survival Rate
IF 1.994
Human and Animal Cells WI-38(RCB0702) MDA-MB-453(RCB1192)