Reference - Detail
| RRC ID | 77416 |
|---|---|
| Author | Saito K, Ishizu H, Komai M, Kotani H, Kawamura Y, Nishida KM, Siomi H, Siomi MC. |
| Title | Roles for the Yb body components Armitage and Yb in primary piRNA biogenesis in Drosophila. |
| Journal | Genes Dev |
| Abstract |
PIWI-interacting RNAs (piRNAs) protect genome integrity from transposons. In Drosophila ovarian somas, primary piRNAs are produced and loaded onto Piwi. Here, we describe roles for the cytoplasmic Yb body components Armitage and Yb in somatic primary piRNA biogenesis. Armitage binds to Piwi and is required for localizing Piwi into Yb bodies. Without Armitage or Yb, Piwi is freed from the piRNAs and does not enter the nucleus. Thus, piRNA loading is required for Piwi nuclear entry. We propose that a functional Piwi-piRNA complex is formed and inspected in Yb bodies before its nuclear entry to exert transposon silencing. |
| Volume | 24(22) |
| Pages | 2493-8 |
| Published | 2010-11-15 |
| DOI | 10.1101/gad.1989510 |
| PII | gad.1989510 |
| PMID | 20966047 |
| PMC | PMC2975925 |
| MeSH | Animals Cell Line Cell Nucleus / metabolism Cytoplasm / metabolism DNA Transposable Elements / physiology Drosophila Proteins / metabolism* Drosophila melanogaster / metabolism Drosophila melanogaster / physiology* Endoribonucleases / metabolism Protein Transport RNA Helicases / metabolism* RNA, Small Interfering / biosynthesis* |
| IF | 9.527 |
| Altmetric score |
オルトメトリクス指標項目
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| Total number of mentions | 0 |
| Resource | |
| Drosophila | 10011Ab-1 10012Ab-1 |