Reference - Detail
| RRC ID | 77508 |
|---|---|
| Author | Noguchi H, Matsushita M, Okitsu T, Moriwaki A, Tomizawa K, Kang S, Li ST, Kobayashi N, Matsumoto S, Tanaka K, Tanaka N, Matsui H. |
| Title | A new cell-permeable peptide allows successful allogeneic islet transplantation in mice. |
| Journal | Nat Med |
| Abstract |
Calcineurin inhibitors such as cyclosporine A and FK506 have been used for transplant therapy and treatment of autoimmune diseases. However, the inhibition of calcineurin outside the immune system has a number of side effects, including hyperglycemia. In the search for safer drugs, we developed a cell-permeable inhibitor of NFAT (nuclear factor of activated T cells) using the polyarginine peptide delivery system. This peptide provided immunosuppression for fully mismatched islet allografts in mice. In addition, it did not affect insulin secretion, whereas FK506 caused a dose-dependent decrease in insulin secretion. Cell-permeable peptides can thus provide a new strategy for drug development and may eventually be useful clinically. |
| Volume | 10(3) |
| Pages | 305-9 |
| Published | 2004-3-1 |
| DOI | 10.1038/nm994 |
| PII | nm994 |
| PMID | 14770176 |
| MeSH | Animals DNA-Binding Proteins / antagonists & inhibitors* DNA-Binding Proteins / metabolism Graft Survival Humans Immunosuppressive Agents / metabolism Immunosuppressive Agents / pharmacology* Insulin / metabolism Insulin Secretion Interleukin-2 / metabolism Islets of Langerhans / drug effects Islets of Langerhans / metabolism Islets of Langerhans Transplantation* Jurkat Cells Lymphocyte Activation Mice Mice, Inbred BALB C Mice, Inbred C3H NFATC Transcription Factors Nuclear Proteins* Oligopeptides / chemistry Oligopeptides / genetics Oligopeptides / metabolism Peptides Permeability Recombinant Fusion Proteins / pharmacology* T-Lymphocytes / immunology T-Lymphocytes / metabolism Tacrolimus / metabolism Tacrolimus / pharmacology Transcription Factors / antagonists & inhibitors* Transcription Factors / metabolism Transplantation, Homologous |
| IF | 36.13 |
| Resource | |
| Human and Animal Cells | Jurkat(RCB0806) |