論文 - 詳細
| RRC ID | 77532 |
|---|---|
| 著者 | Miyamoto-Sasaki M, Yasuda T, Monguchi T, Nakajima H, Mori K, Toh R, Ishida T, Hirata K. |
| タイトル | Pitavastatin increases HDL particles functionally preserved with cholesterol efflux capacity and antioxidative actions in dyslipidemic patients. |
| ジャーナル | J Atheroscler Thromb |
| Abstract |
AIM:Although statins increase the plasma concentration of high-density lipoprotein cholesterol (HDL-C), it has not been elucidated whether the increased HDL particles possess normal antiatherosclerotic properties. Pitavastatin functions to increase the plasma HDL-C level and decrease the lowdensity lipoprotein cholesterol (LDL-C) level. In the present study, we sought to examine the qualitative changes in HDL during pitavastatin treatment. METHODS:A total of 30 patients with dyslipidemia were treated with 2 mg of pitavastatin for four weeks. The cholesterol efflux capacity and activities of the antioxidative enzymes paraoxonase-1 (PON-1) and platelet-activating factor acetylhydrolase (PAF-AH) were evaluated using polyethethylene glycol-treated HDL fractions before and after pitavastatin treatment. RESULTS:Pitavastatin treatment decreased the serum LDL-C level by 39% and increased the serum HDL-C level by 9% (p＜0.05). In addition, pitavastatin increased the phospholipid content of HDL by 7.8% (p＜0.05). The pitavastatin-induced increase in the HDL-C level coincided with an increase in the cholesterol efflux capacity of the isolated HDL fraction of 8.6% (p＜0.05). The post-pitavastatin treatment activity of HDL-associated PON-1 (paraoxonase and arylesterase) was increased by 9% (p＜0.05) and 11% (p＜0.05), respectively, while the HDL-associated PAF-AH activity was not affected by pitavastatin. CONCLUSIONS:In addition to its LDL-C-lowering effects, pitavastatin elevates the HDL-C level and enhances the cholesterol efflux capacity and antioxidative properties of HDL. Pitavastatin therefore increases the amount of functional HDL without attenuating HDL quality. |
| 巻・号 | 20(9) |
| ページ | 708-16 |
| 公開日 | 2013-1-1 |
| DOI | 10.5551/jat.17210 |
| PII | DN/JST.JSTAGE/jat/17210 |
| PMID | 23739642 |
| MeSH | 1-Alkyl-2-acetylglycerophosphocholine Esterase / metabolism Adult Aged Antioxidants / metabolism Aryldialkylphosphatase / metabolism Atherosclerosis / prevention & control Cholesterol / metabolism Cholesterol, HDL / drug effects* Dyslipidemias / drug therapy* Dyslipidemias / metabolism* Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology Male Middle Aged Platelet Activating Factor / metabolism Polyethylene Glycols / metabolism Quinolines / pharmacology* |
| IF | 3.876 |
| リソース情報 | |
| ヒト・動物細胞 | THP-1(RCB1189) |