RRC ID 77561
Author Kono A, Shikano Y, Tanaka KF, Yamaura K, Tsutsui-Kimura I.
Title Inhibition of the dorsomedial striatal direct pathway is essential for the execution of action sequences.
Journal Neuropsychopharmacol Rep
Abstract Contrary to the previous notion that the dorsomedial striatum (DMS) is crucial for acquiring new learning, accumulated evidence has suggested that the DMS also plays a role in the execution of already learned action sequences. Here, we examined how the direct and indirect pathways in the DMS regulate action sequences using a task that requires animals to press a lever consecutively. Cell-type-specific bulk Ca2+ recording revealed that the direct pathway was inhibited at the time of sequence execution. The sequence-related response was blunted in trials where the sequential behaviors were disrupted. Optogenetic activation at the sequence start caused distraction of action sequences without affecting motor function or memory of the task structure. By contrast with the direct pathway, the indirect pathway was slightly activated at the start of the sequence, but the optogenetic suppression of such sequence-related signaling did not impact the behaviors. These results suggest that the inhibition of the DMS direct pathway promotes sequence execution potentially by suppressing the formation of a new association.
Volume 43(3)
Pages 414-424
Published 2023-9-1
DOI 10.1002/npr2.12369
PMID 37553985
PMC PMC10496086
MeSH Animals Corpus Striatum* Learning* Signal Transduction
Mice RBRC05454 RBRC05842 RBRC02317