Reference - Detail
| RRC ID | 77577 |
|---|---|
| Author | Yamazaki Y, Abe Y, Fujii S, Tanaka KF. |
| Title | Oligodendrocytic Na+-K+-Cl- co-transporter 1 activity facilitates axonal conduction and restores plasticity in the adult mouse brain. |
| Journal | Nat Commun |
| Abstract |
The juvenile brain presents plasticity. Oligodendrocytes are the myelinating cells of the central nervous system and myelination can be adaptive. Plasticity decreases from juvenile to adulthood. The mechanisms involving oligodendrocytes underlying plasticity are unclear. Here, we show Na+-K+-Cl- co-transporter 1 (NKCC1), highly expressed in the juvenile mouse brain, regulates the oligodendrocyte activity from juvenile to adulthood in mice, as shown by optogenetic manipulation of oligodendrocytes. The reduced neuronal activity in adults was restored by Nkcc1 overexpression in oligodendrocytes. Moreover, in adult mice overexpressing Nkcc1, long-term potentiation and learning were facilitated compared to age-matched controls. These findings demonstrate that NKCC1 plays a regulatory role in the age-dependent activity of oligodendrocytes, furthermore inducing activation of NKCC1 in oligodendrocytes can restore neuronal plasticity in the adult mouse brain. |
| Volume | 12(1) |
| Pages | 5146 |
| Published | 2021-8-26 |
| DOI | 10.1038/s41467-021-25488-5 |
| PII | 10.1038/s41467-021-25488-5 |
| PMID | 34446732 |
| PMC | PMC8390751 |
| MeSH | Animals Axons / metabolism* Brain / cytology Brain / physiology* Female Learning Male Mice Neuronal Plasticity* Neurons / metabolism Oligodendroglia / metabolism* Solute Carrier Family 12, Member 2 / genetics Solute Carrier Family 12, Member 2 / metabolism* |
| IF | 12.121 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 9 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Mice | RBRC11202 RBRC05447 RBRC05446 RBRC05454 |