論文 - 詳細
| RRC ID | 77604 |
|---|---|
| 著者 | Srimontri P, Endo S, Sakamoto T, Nakayama Y, Kurosaka A, Itohara S, Hirabayashi Y, Kato K. |
| タイトル | Sialyltransferase ST3Gal IV deletion protects against temporal lobe epilepsy. |
| ジャーナル | J Neurochem |
| Abstract |
Temporal lobe epilepsy (TLE) often becomes refractory, and patients with TLE show a high incidence of psychiatric symptoms, including anxiety and depression. Therefore, it is necessary to identify molecules that were previously unknown to contribute to epilepsy and its associated disorders. We previously found that the sialyltransferase ST3Gal IV is up-regulated within the neural circuits through which amygdala-kindling stimulation propagates epileptic seizures. In contrast, this study demonstrated that kindling stimulation failed to evoke epileptic seizures in ST3Gal IV-deficient mice. Furthermore, approximately 80% of these mice failed to show tonic-clonic seizures with stimulation, whereas all littermate wild-type mice showed tonic-clonic seizures. This indicates that the loss of ST3Gal IV does not cause TLE in mice. Meanwhile, ST3Gal IV-deficient mice exhibited decreased acclimation in the open field test, increased immobility in the forced swim test, enhanced freezing during delay auditory fear conditioning, and sleep disturbances. Thus, the loss of ST3Gal IV modulates anxiety-related behaviors. These findings indicate that ST3Gal IV is a key molecule in the mechanisms underlying anxiety - a side effect of TLE - and may therefore also be an effective target for treating epilepsy, acting through the same circuits. |
| 巻・号 | 131(5) |
| ページ | 675-87 |
| 公開日 | 2014-12-1 |
| DOI | 10.1111/jnc.12838 |
| PMID | 25066807 |
| MeSH | Animals Conditioning, Psychological / physiology Disease Models, Animal Electric Stimulation / adverse effects Electroencephalography Epilepsy, Temporal Lobe / etiology Epilepsy, Temporal Lobe / genetics Epilepsy, Temporal Lobe / physiopathology Epilepsy, Temporal Lobe / prevention & control* Exploratory Behavior / physiology Fear / psychology Hindlimb Suspension Hippocampus / physiopathology Kindling, Neurologic / genetics Mice Mice, Inbred C57BL Mice, Transgenic Sequence Deletion / genetics* Sialyltransferases / deficiency* Sialyltransferases / genetics Sleep / genetics Swimming / psychology beta-Galactoside alpha-2,3-Sialyltransferase |
| IF | 4.066 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC02285 |