| RRC ID |
77770
|
| 著者 |
Casella V, Domenjo-Vila E, Esteve-Codina A, Pedragosa M, Cebollada Rica P, Vidal E, de la Rubia I, López-Rodríguez C, Bocharov G, Argilaguet J, Meyerhans A.
|
| タイトル |
Differential kinetics of splenic CD169+ macrophage death is one underlying cause of virus infection fate regulation.
|
| ジャーナル |
Cell Death Dis
|
| Abstract |
Acute infection and chronic infection are the two most common fates of pathogenic virus infections. While several factors that contribute to these fates are described, the critical control points and the mechanisms that underlie infection fate regulation are incompletely understood. Using the acute and chronic lymphocytic choriomeningitis virus (LCMV) infection model of mice, we find that the early dynamic pattern of the IFN-I response is a differentiating trait between both infection fates. Acute-infected mice generate a 2-wave IFN-I response while chronic-infected mice generate only a 1-wave response. The underlying cause is a temporal difference in CD8 T cell-mediated killing of splenic marginal zone CD169+ macrophages. It occurs later in acute infection and thus enables CD169+ marginal zone macrophages to produce the 2nd IFN-I wave. This is required for subsequent immune events including induction of inflammatory macrophages, generation of effector CD8+ T cells and virus clearance. Importantly, these benefits come at a cost for the host in the form of spleen fibrosis. Due to an earlier marginal zone destruction, these ordered immune events are deregulated in chronic infection. Our findings demonstrate the critical importance of kinetically well-coordinated sequential immune events for acute infection control and highlights that it may come at a cost for the host organism.
|
| 巻・号 |
14(12)
|
| ページ |
838
|
| 公開日 |
2023-12-18
|
| DOI |
10.1038/s41419-023-06374-y
|
| PII |
10.1038/s41419-023-06374-y
|
| PMID |
38110339
|
| PMC |
PMC10728219
|
| MeSH |
Animals
CD8-Positive T-Lymphocytes
Lymphocytic Choriomeningitis* / pathology
Lymphocytic choriomeningitis virus / physiology
Macrophages / pathology
Mice
Mice, Inbred C57BL
Persistent Infection
|
| IF |
6.304
|
| リソース情報 |
| 実験動物マウス |
RBRC04395 |
