論文 - 詳細
| RRC ID | 77788 |
|---|---|
| 著者 | Muraoka Y, Muramoto J, Yasuhara Y, Kawatake M, Sakamoto T. |
| タイトル | Near-Infrared Fluorescent Switch-On Probe for Guanine-Quadruplex Imaging with Extremely Large Stokes Shift. |
| ジャーナル | Anal Chem |
| Abstract |
To visualize the guanine-quadruplex (G4) nucleic acids in cells or in biological tissues, near-infrared (NIR) fluorescent probes that can respond specifically to G4 nucleic acids are required. Herein, an NIR fluorescence switch-on probe for G4 imaging having higher selectivity and extremely large Stokes shift (ca. 220 nm) was successfully developed by the modification of our original tripodal quinone-cyanine fluorescent dye. The target binding-induced intramolecular stacking interaction of the probe might cause red shifting of the fluorescence emission. The NIR fluorescence switch-on probe developed here might contribute largely to revealing the behaviors of G4 nucleic acids not only in cells but also in biological tissues. |
| 巻・号 | 95(47) |
| ページ | 17162-17165 |
| 公開日 | 2023-11-28 |
| DOI | 10.1021/acs.analchem.3c04318 |
| PMID | 37955574 |
| MeSH | Fluorescent Dyes* Nucleic Acids* Optical Imaging |
| IF | 6.785 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | HeLa(RCB0007) |