| RRC ID |
77788
|
| 著者 |
Muraoka Y, Muramoto J, Yasuhara Y, Kawatake M, Sakamoto T.
|
| タイトル |
Near-Infrared Fluorescent Switch-On Probe for Guanine-Quadruplex Imaging with Extremely Large Stokes Shift.
|
| ジャーナル |
Anal Chem
|
| Abstract |
To visualize the guanine-quadruplex (G4) nucleic acids in cells or in biological tissues, near-infrared (NIR) fluorescent probes that can respond specifically to G4 nucleic acids are required. Herein, an NIR fluorescence switch-on probe for G4 imaging having higher selectivity and extremely large Stokes shift (ca. 220 nm) was successfully developed by the modification of our original tripodal quinone-cyanine fluorescent dye. The target binding-induced intramolecular stacking interaction of the probe might cause red shifting of the fluorescence emission. The NIR fluorescence switch-on probe developed here might contribute largely to revealing the behaviors of G4 nucleic acids not only in cells but also in biological tissues.
|
| 巻・号 |
95(47)
|
| ページ |
17162-17165
|
| 公開日 |
2023-11-28
|
| DOI |
10.1021/acs.analchem.3c04318
|
| PMID |
37955574
|
| MeSH |
Fluorescent Dyes*
Nucleic Acids*
Optical Imaging
|
| IF |
6.785
|
| リソース情報 |
| ヒト・動物細胞 |
HeLa(RCB0007) |
