Reference - Detail
| RRC ID | 77815 |
|---|---|
| Author | Ines Ambite, Thi Hien Tran, Daniel S. C. Butler, Michele Cavalera, Murphy Lam Yim Wan, Shahram Ahmadi, Catharina Svanborg |
| Title | Therapeutic Effects of IL-1RA against Acute Bacterial Infections, including Antibiotic-Resistant Strains |
| Journal | Pathogens |
| Abstract |
Innate immunity is essential for the anti-microbial defense, but excessive immune activation may cause severe disease. In this study, immunotherapy was shown to prevent excessive innate immune activation and restore the anti-bacterial defense. E. coli-infected Asc−/− mice develop severe acute cystitis, defined by IL-1 hyper-activation, high bacterial counts, and extensive tissue pathology. Here, the interleukin-1 receptor antagonist (IL-1RA), which inhibits IL-1 hyper-activation in acute cystitis, was identified as a more potent inhibitor of inflammation and NK1R- and substance P-dependent pain than cefotaxime. Furthermore, IL-1RA treatment inhibited the excessive innate immune activation in the kidneys of infected Irf3−/− mice and restored tissue integrity. Unexpectedly, IL-1RA also accelerated bacterial clearance from infected bladders and kidneys, including antibiotic-resistant E. coli, where cefotaxime treatment was inefficient. The results suggest that by targeting the IL-1 response, control of the innate immune response to infection may be regained, with highly favorable treatment outcomes, including infections caused by antibiotic-resistant strains. |
| Volume | 13 |
| Pages | 42 |
| Published | 2023-12-31 |
| DOI | 10.3390/pathogens13010042 |
| PMID | 38251349 |
| PMC | PMC10820880 |
| IF | 3.018 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | |
| Total number of mentions | 5 |
| Altmetric score changes over past 6months | 0.2 |
| Resource | |
| Mice | RBRC00858 |