Reference - Detail
| RRC ID | 77839 |
|---|---|
| Author | Kim HJ, Park JH, Kim HC, Kim CW, Kang I, Lee HK. |
| Title | Blood monocyte-derived CD169+ macrophages contribute to antitumor immunity against glioblastoma. |
| Journal | Nat Commun |
| Abstract |
Infiltrating tumor-associated macrophages (TAM) are known to impede immunotherapy against glioblastoma (GBM), however, TAMs are heterogeneous, and there are no clear markers to distinguish immunosuppressive and potentially immune-activating populations. Here we identify a subset of CD169+ macrophages promoting an anti-tumoral microenvironment in GBM. Using single-cell transcriptome analysis, we find that CD169+ macrophages in human and mouse gliomas produce pro-inflammatory chemokines, leading to the accumulation of T cells and NK cells. CD169 expression on macrophages facilitates phagocytosis of apoptotic glioma cells and hence tumor-specific T cell responses. Depletion of CD169+ macrophages leads to functionally impaired antitumor lymphocytes and poorer survival of glioma-bearing mice. We show that NK-cell-derived IFN-γ is critical for the accumulation of blood monocyte-derived CD169+ macrophages in gliomas. Our work thus identifies a well-distinguished TAM subset promoting antitumor immunity against GBM, and identifies key factors that might shift the balance from immunosuppressive to anti-tumor TAM. |
| Volume | 13(1) |
| Pages | 6211 |
| Published | 2022-10-20 |
| DOI | 10.1038/s41467-022-34001-5 |
| PII | 10.1038/s41467-022-34001-5 |
| PMID | 36266311 |
| PMC | PMC9585054 |
| MeSH | Animals Brain Neoplasms* / metabolism Glioblastoma* / metabolism Glioma* / pathology Humans Killer Cells, Natural Macrophages / metabolism Mice Monocytes / metabolism Tumor Microenvironment |
| IF | 12.121 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 36 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Mice | RBRC04395 |