Reference - Detail
| RRC ID | 77860 |
|---|---|
| Author | Suginoma H, Owada R, Katano-Toki A, Mori A, Fujioka J, Nakamura K. |
| Title | Non-fibril form but not fibril form of human islet amyloid polypeptide 8-20 changes brain functions in mice. |
| Journal | PLoS One |
| Abstract |
Whether fibril formation increases or decreases cytotoxicity remains unclear. Aggregation of human islet amyloid polypeptide (hIAPP), a pivotal regulator of glucose homeostasis, impairs the function and viability of pancreatic β cells. Evidence suggests that low-order oligomers of hIAPP are more toxic to β cells than fibril. However, it remains unclear whether non-fibril form of hIAPP specifically alters brain functions. This study produced fibril and non-fibril forms from a single hIAPP 8-20 peptide. The non-fibril form-injected mice showed changes in spontaneous motor activities, preference for location in the open field and social behavior. In contrast, the fibril-injected mice showed no changes in these behavioral tests. In line with the behavioral changes, the non-fibril form led to impaired neurite outgrowth of cultured neuron-like cells and the loss of neurons in the mouse hippocampus. These findings suggest that non-fibril form but not fibril form of hIAPP changes brain functions. |
| Volume | 19(1) |
| Pages | e0296750 |
| Published | 2024-1-1 |
| DOI | 10.1371/journal.pone.0296750 |
| PII | PONE-D-23-10509 |
| PMID | 38181010 |
| PMC | PMC10769099 |
| MeSH | Animals Brain Cytoskeleton Humans Islet Amyloid Polypeptide Mice Nervous System Physiological Phenomena* Peptide Hormones* |
| IF | 2.74 |
| Altmetric score |
オルトメトリクス指標項目
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| Total number of mentions | 0 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | PC-12(RCB0009) |