論文 - 詳細
| RRC ID | 77887 |
|---|---|
| 著者 | Matsuda H, Nakashima S, Oda Y, Nakamura S, Yoshikawa M. |
| タイトル | Melanogenesis inhibitors from the rhizomes of Alpinia officinarum in B16 melanoma cells. |
| ジャーナル | Bioorg Med Chem |
| Abstract |
The 80% aqueous acetone extract from the rhizomes of Alpinia officinarum, a Chinese medicinal herb, were found to inhibit melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells. Among the constituents isolated, four diarylheptanoids [5-hydroxy-1,7-diphenyl-3-heptanone, 7-(4('')-hydroxy-3('')-methoxyphenyl)-1-phenylhept-4-en-3-one, 5-hydroxy-7-(4('')-hydroxy-3('')-methoxyphenyl)-1-phenyl-3-heptanone, and 3,5-dihydroxy-1,7-diphenylheptane] and two flavonol constituents (kaempferide and galangin) inhibited melanogenesis with IC(50) values of 10-48microM, and several structural requirements of the active constituents for the inhibition were clarified. In addition, 7-(4('')-hydroxy-3('')-methoxyphenyl)-1-phenylhept-4-en-3-one, kaempferide, and galangin inhibited mRNA expression of tyrosinase and tyrosinase-related proteins-1 and -2, and the protein level of a microphthalmia-associated transcription factor. |
| 巻・号 | 17(16) |
| ページ | 6048-53 |
| 公開日 | 2009-8-15 |
| DOI | 10.1016/j.bmc.2009.06.057 |
| PII | S0968-0896(09)00616-6 |
| PMID | 19615910 |
| MeSH | Alpinia / chemistry* Animals Antineoplastic Agents / chemistry* Antineoplastic Agents / isolation & purification Antineoplastic Agents / pharmacology Enzyme Inhibitors / chemistry* Enzyme Inhibitors / isolation & purification Enzyme Inhibitors / pharmacology Flavonoids / chemistry Flavonoids / isolation & purification Flavonoids / pharmacology Kaempferols / chemistry Kaempferols / isolation & purification Kaempferols / pharmacology Melanoma, Experimental / drug therapy* Mice Monophenol Monooxygenase / antagonists & inhibitors* Monophenol Monooxygenase / metabolism Oxidoreductases / antagonists & inhibitors Oxidoreductases / metabolism Rhizome / chemistry |
| IF | 3.073 |
| リソース情報 | |
| ヒト・動物細胞 | B16 melanoma 4A5(RCB0557) |