| RRC ID |
77899
|
| 著者 |
Arung ET, Furuta S, Ishikawa H, Tanaka H, Shimizu K, Kondo R.
|
| タイトル |
Melanin biosynthesis inhibitory and antioxidant activities of quercetin-3'-O-beta-D-glucoside isolated from Allium cepa.
|
| ジャーナル |
Z Naturforsch C J Biosci
|
| Abstract |
In the course of searching for new whitening agents, we have found that the methanol extract of dried skin of Allium cepa shows potent melanin biosynthesis inhibitory activity in B16 melanoma cells. Bioassay-guided fractionation led to the isolation of quercetin-3'-O-beta-D-glucoside (1) from the methanol extract of dried skin of A. cepa, which inhibited melanin formation in B16 melanoma cells with an IC50 value of 38.8 microM and mushroom tyrosinase with an IC50 value of 6.5 microM using L-tyrosine and 48.5 microM using L-dihydroxyphenylalanine as substrates, respectively. In addition, the antioxidant activity of 1 was evaluated in the oxygen radical absorbance capacity assay; it showed 3.04 micromol Trolox equivalents/mmol. 1 was shown to be a promising ingredient that could be useful for treating hyperpigmentation and for protecting against oxidative stress.
|
| 巻・号 |
66(5-6)
|
| ページ |
209-14
|
| 公開日 |
2011-1-1
|
| DOI |
10.1515/znc-2011-5-603
|
| PMID |
21812337
|
| MeSH |
Allium / chemistry*
Animals
Antioxidants / pharmacology*
Cell Line, Tumor
Chromatography, High Pressure Liquid
Flavonoids / isolation & purification
Flavonoids / pharmacology*
Glucosides
Melanins / antagonists & inhibitors*
Melanins / biosynthesis
Melanoma, Experimental / pathology
Mice
Quercetin / analogs & derivatives
|
| IF |
1.238
|
| リソース情報 |
| ヒト・動物細胞 |
B16 melanoma 4A5(RCB0557) |
