Reference - Detail
| RRC ID | 77902 |
|---|---|
| Author | Fujimoto K, Nakamura S, Nakashima S, Matsumoto T, Uno K, Ohta T, Miura T, Matsuda H, Yoshikawa M. |
| Title | Medicinal flowers. XXXV. Nor-oleanane-type and acylated oleanane-type triterpene saponins from the flower buds of Chinese Camellia japonica and their inhibitory effects on melanogenesis. |
| Journal | Chem Pharm Bull (Tokyo) |
| Abstract |
The methanolic extract and its 1-butanol-soluble fraction from the flower buds of Camellia japonica, cultivated in Yunnan Province, China, showed inhibitory effects on melanogenesis in theophylline-stimulated B16 melanoma 4A5 cells. From the 1-butanol-soluble fraction, a new 28-nor-oleanane-type and three new oleanane-type triterpene saponins, sanchakasaponins A-D, were isolated together with four known triterpene saponins. Their chemical structures were elucidated on the basis of chemical and physicochemical evidence. The inhibitory effects on melanogenesis in theophylline-stimulated B16 melanoma 4A5 cells and structure-activity relationships of the saponins were investigated. |
| Volume | 60(9) |
| Pages | 1188-94 |
| Published | 2012-1-1 |
| DOI | 10.1248/cpb.c12-00473 |
| PII | DN/JST.JSTAGE/cpb/c12-00473 |
| PMID | 22976329 |
| MeSH | Animals Antineoplastic Agents, Phytogenic / chemistry* Antineoplastic Agents, Phytogenic / isolation & purification Antineoplastic Agents, Phytogenic / pharmacology* Camellia / chemistry* Cell Line, Tumor Flowers / chemistry Melanins / antagonists & inhibitors* Melanins / metabolism Melanoma, Experimental / drug therapy* Melanoma, Experimental / metabolism Mice Oleanolic Acid / chemistry* Oleanolic Acid / isolation & purification Oleanolic Acid / pharmacology* Structure-Activity Relationship |
| IF | 1.416 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 3 |
| Altmetric score changes over past 6months | 3.0 |
| Resource | |
| Human and Animal Cells | B16 melanoma 4A5(RCB0557) |