| RRC ID |
78036
|
| 著者 |
Matsuka M, Otsune S, Sugimori S, Tsugita Y, Ueda H, Nakagoshi H.
|
| タイトル |
Fecundity is optimized by levels of nutrient signal-dependent expression of Dve and EcR in Drosophila male accessory gland.
|
| ジャーナル |
Dev Biol
|
| Abstract |
Steroid hormones play various physiological roles including metabolism and reproduction. Steroid hormones in insects are ecdysteroids, and the major form in Drosophila melanogaster is ecdysone. In Drosophila males, the accessory gland is responsive to nutrient-dependent regulation of fertility/fecundity. The accessory gland is composed of two types of binucleated epithelial cells: a main cell and a secondary cell (SC). The transcription factors Defective proventriculus (Dve), Abdominal-B, and Ecdysone receptors (EcRs) are strongly expressed in adult SCs. We show that this EcR expression is regulated by parallel pathways of nutrient signaling and the Dve activity. Induction of Dve expression is also dependent on nutrient signaling, and it becomes nutrient signal-independent during a restricted period of development. Forced dve expression during the restricted period significantly increased the number of SCs. Here, we provide evidence that the level of nutrient signal-dependent Dve expression during the restricted period determines the number of SCs, and that ecdysone signaling is also crucial to optimize male fecundity through nutrient signal-dependent survival and maturation of SCs.
|
| 巻・号 |
508
|
| ページ |
8-23
|
| 公開日 |
2024-1-8
|
| DOI |
10.1016/j.ydbio.2024.01.004
|
| PII |
S0012-1606(24)00004-6
|
| PMID |
38199580
|
| MeSH |
Animals
Drosophila / metabolism
Drosophila Proteins* / genetics
Drosophila Proteins* / metabolism
Drosophila melanogaster / metabolism
Ecdysone / metabolism
Fertility
Male
Receptors, Steroid* / genetics
Receptors, Steroid* / metabolism
Steroids / metabolism
|
| IF |
2.896
|
| リソース情報 |
| ショウジョウバエ |
5092R-2
DGRC#109130
DGRC#109131
DGRC#109173
DGRC#109175 |
