| RRC ID |
78237
|
| Author |
Tanaka T, Takahashi K, Inoue Y, Endo N, Shimoda E, Ueno K, Ichiyanagi T, Ohta T, Ishihara A.
|
| Title |
Inhibition of melanoma cell proliferation by strobilurins isolated from mushrooms and their synthetic analogues.
|
| Journal |
Biosci Biotechnol Biochem
|
| Abstract |
Strobilurins A and X, isolated from Mucidula venosolamellata cluture extracts, demonstrated potent inhibition of human melanoma G-361 cell proliferation. Strobilurin X exhibited milder inhibitory effects on human fibroblast cells (NB1RGB) compared to strobilurin A. Additional strobilurin-related compounds were isolated from the other mushroom species. Oudemansins A and B displayed weaker activities on G-361 cells than strobilurins A and B, respectively, emphasizing the importance of a conjugated double-bond structure. Among isolated compounds, strobilurin G showed the lowest IC50 value for G-361 cells. Additional strobilurins bearing various substituents on the benzene ring were synthesised. Synthetic intermediates lacking the methyl β-methoxyacrylate group and a strobilurin analogue bearing modified β-methoxyacrylate moiety showed almost no inhibitory activity against G-361 cells. The introduction of long or bulky substituents at the 4'-position of the benzene ring of strobilurins enhanced the activity and selectivity, suggesting differential recognition of the benzene ring by G-361 and NB1RGB cells.
|
| Published |
2024-1-25
|
| DOI |
10.1093/bbb/zbae006
|
| PII |
7589712
|
| PMID |
38271595
|
| MeSH |
Agaricales*
Benzene
Cell Proliferation
Fungicides, Industrial* / chemistry
Fungicides, Industrial* / pharmacology
Humans
Melanoma*
Strobilurins / chemistry
|
| IF |
1.516
|
| Resource |
| Human and Animal Cells |
NB1RGB(RCB0222) |
| Fungus/Mushroom |
TUFC30333
TUFC12963
TUFC11891 |
