Reference - Detail
| RRC ID | 78237 |
|---|---|
| Author | Tanaka T, Takahashi K, Inoue Y, Endo N, Shimoda E, Ueno K, Ichiyanagi T, Ohta T, Ishihara A. |
| Title | Inhibition of melanoma cell proliferation by strobilurins isolated from mushrooms and their synthetic analogues. |
| Journal | Biosci Biotechnol Biochem |
| Abstract |
Strobilurins A and X, isolated from Mucidula venosolamellata cluture extracts, demonstrated potent inhibition of human melanoma G-361 cell proliferation. Strobilurin X exhibited milder inhibitory effects on human fibroblast cells (NB1RGB) compared to strobilurin A. Additional strobilurin-related compounds were isolated from the other mushroom species. Oudemansins A and B displayed weaker activities on G-361 cells than strobilurins A and B, respectively, emphasizing the importance of a conjugated double-bond structure. Among isolated compounds, strobilurin G showed the lowest IC50 value for G-361 cells. Additional strobilurins bearing various substituents on the benzene ring were synthesised. Synthetic intermediates lacking the methyl β-methoxyacrylate group and a strobilurin analogue bearing modified β-methoxyacrylate moiety showed almost no inhibitory activity against G-361 cells. The introduction of long or bulky substituents at the 4'-position of the benzene ring of strobilurins enhanced the activity and selectivity, suggesting differential recognition of the benzene ring by G-361 and NB1RGB cells. |
| Published | 2024-1-25 |
| DOI | 10.1093/bbb/zbae006 |
| PII | 7589712 |
| PMID | 38271595 |
| MeSH | Agaricales* Benzene Cell Proliferation Fungicides, Industrial* / chemistry Fungicides, Industrial* / pharmacology Humans Melanoma* Strobilurins / chemistry |
| IF | 1.516 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | NB1RGB(RCB0222) |
| Fungus/Mushroom | TUFC30333 TUFC12963 TUFC11891 |