論文 - 詳細
| RRC ID | 78265 |
|---|---|
| 著者 | Lee JG, Yon JM, Kim G, Lee SG, Kim CY, Cheong SA, Kim HY, Yu J, Kim K, Sung YH, Yoo HJ, Woo DC, Rho JK, Ha CH, Pack CG, Oh SH, Lim JS, Han YM, Hong EJ, Seong JK, Lee HW, Lee SW, Lee KU, Kim CJ, Nam SY, Cho YS, Baek IJ. |
| タイトル | PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development. |
| ジャーナル | Nat Commun |
| Abstract |
Proper placental development in early pregnancy ensures a positive outcome later on. The developmental relationship between the placenta and embryonic organs, such as the heart, is crucial for a normal pregnancy. However, the mechanism through which the placenta influences the development of embryonic organs remains unclear. Trophoblasts fuse to form multinucleated syncytiotrophoblasts (SynT), which primarily make up the placental materno-fetal interface. We discovered that endogenous progesterone immunomodulatory binding factor 1 (PIBF1) is vital for trophoblast differentiation and fusion into SynT in humans and mice. PIBF1 facilitates communication between SynT and adjacent vascular cells, promoting vascular network development in the primary placenta. This process affected the early development of the embryonic cardiovascular system in mice. Moreover, in vitro experiments showed that PIBF1 promotes the development of cardiovascular characteristics in heart organoids. Our findings show how SynTs organize the barrier and imply their possible roles in supporting embryogenesis, including cardiovascular development. SynT-derived factors and SynT within the placenta may play critical roles in ensuring proper organogenesis of other organs in the embryo. |
| 巻・号 | 15(1) |
| ページ | 1487 |
| 公開日 | 2024-2-19 |
| DOI | 10.1038/s41467-024-45647-8 |
| PII | 10.1038/s41467-024-45647-8 |
| PMID | 38374152 |
| PMC | PMC10876648 |
| MeSH | Animals Cell Differentiation Embryonic Development Female Humans Mice Placenta* / metabolism Placentation / physiology Pregnancy Pregnancy Proteins* / genetics Pregnancy Proteins* / metabolism Suppressor Factors, Immunologic / metabolism Trophoblasts / metabolism |
| IF | 12.121 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | CT27(RCB4936) |