| RRC ID |
78351
|
| 著者 |
Sueto D, Onishi A, I E, Yoshikawa Y, Tsuda M.
|
| タイトル |
Laminar-selective spinal astrocyte population capable of converting tactile information into nociceptive in rats.
|
| ジャーナル |
J Pharmacol Sci
|
| Abstract |
We previously identified a spinal astrocyte population that expresses hairy and enhancer of split 5 (Hes5) and is selectively present in superficial laminae in mice. However, it was unclear whether such astrocyte heterogeneity is commonly observed across species. Using adeno-associated viral (AAV) vectors incorporating a rat Hes5 promotor (AAV-Hes5P), we found that AAV-Hes5P-captured astrocytes were selectively located in the superficial laminae in rats. Furthermore, activation of AAV-Hes5P+ astrocytes elicited allodynia-like behavior and increased c-FOS+ cells in the superficial laminae. Thus, laminar-selective Hes5+ astrocytes are conserved beyond species and have the capability to convert tactile information to nociceptive.
|
| 巻・号 |
154(4)
|
| ページ |
312-315
|
| 公開日 |
2024-2-27
|
| DOI |
10.1016/j.jphs.2024.02.014
|
| PII |
S1347-8613(24)00025-2
|
| PMID |
38485349
|
| リソース情報 |
| ラット |
W-Tg(Thy1-COP4/YFP*)4Jfhy (StrainID=1072) |
